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Found 33 clinical trials
Familial Dysglobulinemia (PreFamDys)

from a precursor disease, Monoclonal gammopathy of undetermined significance (MGUS). Despite intensive study, the etiology of MGUS and myeloma are unknown and no lifestyle or environmental exposure

Accepts healthy volunteers
  • 26 views
  • 10 Apr, 2022
  • 31 locations
Rifaximin in Patients With Monoclonal Gammopathy

This trial studies how well rifaximin works in treating patients with monoclonal gammopathy. Antibiotics, such as rifaximin, may help to kill bacteria in the intestines and reduce the abnormal

antibiotics
multiple myeloma
  • 25 views
  • 08 Feb, 2022
  • 1 location
Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

The purpose of this study is to see whether Isatuximab can help improve kidney function of participants with MGRS. Isatuximab is approved by the Food and Drug Administration (FDA) for the treatment of adult patients with multiple myeloma, but it is not approved by the FDA to treat MGRS. This …

  • 0 views
  • 02 Dec, 2021
  • 2 locations
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer

To explore the use of curcumin and piperine supplementation at a dose of 4 gram/5mg twice a day in early stage prostate cancer patient undergoing active surveillance or patients on observation for MGUS/ low-risk smoldering myeloma.

bone marrow procedure
hypercalcemia
cancer
anemia
  • 0 views
  • 15 Jul, 2022
  • 1 location
A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

This study will test whether a plant-based diet is practical (feasible) for overweight people with monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM

  • 18 views
  • 29 Apr, 2022
  • 7 locations
Assessing Glutamine Metabolism in MGUS and Myeloma

The utilization of glutamine by the bone marrow plasma cells in MGUS and MM will be compared between each other after infusion of 13-carbon labelled glutamine.

bone marrow procedure
bone marrow plasma cells
measurable disease
immunoglobulins
  • 15 views
  • 25 Mar, 2022
  • 1 location
Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

The purpose of this research is to understand whether the drug metformin could be used in the future to help prevent patients with monoclonal gammopathy of undetermined significance (MGUS) and

  • 10 views
  • 17 Jun, 2022
  • 7 locations
In-Human CXCR4 Imaging of Blood Cancers Using [68Ga]-Pentixafor-PET

The purpose of this study is to determine the uptake of the imaging agent [68Ga]-pentixafor with PET/CT scans in people with monoclonal gammopathy of undetermined significance (MGUS), smoldering

multiple myeloma
measurable disease
lymphoma
  • 0 views
  • 13 May, 2022
  • 1 location
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma

This study will assess the safety, tolerability, pharmacokinetics (PK) and the therapeutic potential of HDP-101 in patients with plasma cell disorders including multiple myeloma.

measurable disease
refractory multiple myeloma
  • 0 views
  • 07 Mar, 2022
  • 2 locations
ACALA-R In Anti-MAG Neuropathy Mediated Neuropathy

participants with Immunoglobulin (Ig) M monoclonal gammopathy of undetermined significance ( IgM MGUS) or Waldenström macroglobulinemia WM related neuropathies. The names of the study drugs involved in

chronic lymphocytic leukemia
mantle cell lymphoma
immunoglobulin
serum pregnancy test
rituximab
  • 0 views
  • 25 Mar, 2022
  • 2 locations