Found 13 clinical trials
Randomized Trial of Sedative Choice for Intubation (RSI)
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains …
- 0 views
- 04 Oct, 2022
- 1 location
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
This clinical trial is designed to test whether a single stereotactic intracerebral administration of inhibitory nerve cells into subjects with drug-resistant mesial temporal lobe epilepsy is safe (frequency of adverse events) and effective (seizure frequency).
- 0 views
- 04 Apr, 2023
- 9 locations
Latent Aging Mechanisms in Pain and Sleep (LAMPS)
(gamma-aminobutyric acid) in both conditions, based on our preliminary data, this proposal will determine the effect of oral GABA administration in sleep quality and pain in older adults with chronic
- 0 views
- 08 Apr, 2023
- 1 location
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
Background Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric
- 33 views
- 04 Oct, 2022
- 1 location
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
), which was shown to be one of the mechanisms of tDCS effects, the other being changes in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Therefore, to address the above question
- 42 views
- 14 Jul, 2022
- 1 location
Effect of GABA on ADHD and Seizures in Children With Epilepsy.
Effect of GABA on ADHD and seizures in Children with epilepsy.
- 13 views
- 16 Feb, 2022
- 1 location
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Background Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new …
- 106 views
- 11 Apr, 2023
- 1 location
Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus (Ket-Mid)
Generalized convulsive status epilepticus (GCSE) is a common neurological emergency in children. Benzodiazepines are the recommended first line antiseizure medication (ASMs), but they fail to control seizures in a third of cases. Combination of benzodiazepines with another ASM that has a different mechanism of action may be a promising option …
- 0 views
- 06 Apr, 2023
- 1 location
Clarithromycin Mechanisms in Hypersomnia Syndromes
The purpose of this study is to evaluate a medication called clarithromycin for treating sleepiness in two related conditions, narcolepsy without cataplexy and idiopathic hypersomnia. Studies have shown that clarithromycin can reduce sleepiness, but researchers do not know how clarithromycin does this. This study will look at brain activity (on …
- 306 views
- 11 Jul, 2022
- 1 location
Goal-Directed Sedation in Mechanically Ventilated Infants and Children (mini-MENDS)
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs. Universally prescribed sedative medications-the GABA-ergic benzodiazepines-worsen this brain organ dysfunction and independently prolong duration of ventilation and …
- 0 views
- 04 Oct, 2022
- 1 location
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