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Found 10 clinical trials
The Role of the Microbiota-gut-brain Axis in Brain Development and Mental Health

The role of the microbiota-gut-brain axis in brain development and mental health

Accepts healthy volunteers
  • 98 views
  • 03 Mar, 2022
  • 1 location
A Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in Veterans

neurotransmitter, gamma aminobutyric acid (GABA). This novel approach is complimentary to the use of antidepressant medications that primarily target the monoamine systems. Low activity in the PNS and GABA systems

alcohol use disorder
psychotherapy
depression
behavior therapy
remission
  • 21 views
  • 01 Feb, 2022
  • 1 location
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

Background Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric

Accepts healthy volunteers
  • 33 views
  • 04 Oct, 2022
  • 1 location
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

), which was shown to be one of the mechanisms of tDCS effects, the other being changes in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Therefore, to address the above question

Accepts healthy volunteers
neurodegenerative disorders
alzheimer's disease
  • 42 views
  • 14 Jul, 2022
  • 1 location
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Background Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new …

Accepts healthy volunteers
  • 106 views
  • 28 Oct, 2022
  • 1 location
Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

The proposed 3-week, double-blind, crossover, proof of concept study aims to manipulate neurochemical dysfunctions characteristic of individuals with co-occurring BD and AUD (i.e., abnormally low prefrontal GABA and glutamate), using medications that have been shown to normalize cortical GABA (i.e., gabapentin) and glutamate (i.e., NAC) levels in past research, and …

bipolar disorder
gabapentin
alcohol use disorder
acetylcysteine
n-acetylcysteine
  • 200 views
  • 04 Oct, 2022
  • 1 location
Goal-Directed Sedation in Mechanically Ventilated Infants and Children (mini-MENDS)

Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs. Universally prescribed sedative medications-the GABA-ergic benzodiazepines-worsen this brain organ dysfunction and independently prolong duration of ventilation and …

benzodiazepines
  • 0 views
  • 04 Oct, 2022
  • 1 location
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Background Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A drug that blocks these receptors might affect how it works. Objective To see if …

depressive episode
major depressive disorder, single episode
depressed mood
scid
polysomnography
  • 593 views
  • 04 Oct, 2022
  • 1 location
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1 (DoDNAC)

Children with neurofibromatosis type 1 (NF1) commonly suffer from the effects of cognitive, behavioral, and motor impairments. At present, there is no specific treatment for this NF1 complication. In this project, the investigators will assess the safety and clinical benefit of N-acetylcysteine (NAC) as a pharmacological intervention in children with …

Accepts healthy volunteers
  • 2 views
  • 11 Mar, 2022
  • 1 location
Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis (DANCE-AE)

Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody encephalitis), a rare condition which mainly affects children and young people and causes difficulties in memory, thinking and mental health which can have …

Accepts healthy volunteers
  • 0 views
  • 11 Jul, 2022
  • 1 location