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Found 37 clinical trials
PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study) (PLATON)

PLATON (Platform for Analyzing Targetable Mutations) is a prospective, multicentre, observational cohort study with biobanking. In a first approach PLATON's pilot-study assesses genomic profiling in gastrointestinal cancer therapy and the frequencies of targetable mutations including Tumor Mutational Burden (TMB) and Microsatellite Instability Status (MSI), performing Next-generation deep sequencing (NGS) using …

immunostimulants
pancreatic ductal adenocarcinoma
gastrointestinal cancer
cancer
adenocarcinoma
  • 0 views
  • 04 Oct, 2022
  • 30 locations
Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Checkpoint inhibitor therapy represents a significant advance in cancer care. The interaction between PD-1 and PD-L1 induces immune tolerance, and the inhibition of this interaction is an effective treatment strategy for numerous malignancies. Despite its demonstrated potential, immunotherapy is not currently thought to be an effective intervention in the treatment …

peritoneal cancer
measurable disease
cancer
tyrosine
trastuzumab
  • 11 views
  • 16 Sep, 2022
  • 1 location
A Phase Ib/II Study of TT-00420 Tablet, as Monotherapy or in Combination Regimens, to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy in Patients With Advanced Solid Tumor

This is a Phase Ib/II, multicenter, open-label study to evaluate the safety and preliminary efficacy of TT-00420 tablet, as monotherapy or in combination regimens, in patients with advanced solid tumors (solid tumor, BTC and TNBC).

paclitaxel
measurable disease
cancer
bladder tumor
her2/neu-negative breast cancer
  • 0 views
  • 18 Sep, 2022
  • 3 locations
A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering

A clinical trial to assess the safety and efficacy of genetically-engineered, neoantigen-specific Tumor Infiltrating Lymphocytes (TIL) in which the intracellular immune checkpoint CISH has been inhibited using CRISPR gene editing for the treatment of Gastro-Intestinal (GI) Cancer.

laparoscopy
measurable disease
systemic therapy
hepatitis b antigen
filgrastim
  • 53 views
  • 30 Aug, 2021
  • 1 location
Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab

This phase Ib trial studies side effects and best dose of dasatinib in preventing oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancers who are receiving FOLFOX regimen with or without bevacizumab. Drugs used in chemotherapy, such as leucovorin, fluorouracil, and oxaliplatin (FOLFOX regimen), work in different ways to stop the …

bevacizumab
neutrophil count
cancer chemotherapy
thromboplastin
tumor cells
  • 1 views
  • 12 May, 2022
  • 1 location
Study of TT-00420 Tablet as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors

This is a Phase Ib/II, multicenter, open-label study to evaluate the safety and preliminary efficacy of TT-00420 tablet, as monotherapy or in combination regimens, in patients with advanced solid tumors.

paclitaxel
measurable disease
neutrophil count
  • 0 views
  • 04 Oct, 2022
  • 2 locations
A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

metastatic solid tumors including but not limited to gastric cancer/gastroesophageal junction adenocarcinoma, pancreas cancer, gallbladder carcinoma, bile duct carcinoma, lung cancer and ovarian carcinoma

  • 1 views
  • 30 Apr, 2022
  • 3 locations
A Phase I/II Study of M3814 and Avelumab in Combination With Hypofractionated Radiation in Patients With Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth …

antibody therapy
glomerular filtration rate
metastasis
measurable disease
cancer
  • 129 views
  • 20 Sep, 2022
  • 3 locations
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL). Therapeutic virtual reality (VR) has emerged as a promising and evidence-based treatment modality for cancer pain. Users of VR wear a …

cancer
cancer pain
squamous cell carcinoma
carcinoma
cancer pain management
  • 0 views
  • 04 Oct, 2022
  • 1 location
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

patients with biliary tract cancers (BTC), including cholangiocarcinoma (both intrahepatic and extrahepatic) and gallbladder cancer, who are and are physically able to tolerate non-myeloablative

brain metastases
gallbladder cancer
biliary tract cancer
systemic therapy
extrahepatic cholangiocarcinoma
  • 31 views
  • 04 Oct, 2022
  • 1 location