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Found 13 clinical trials
Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial (VOYAGE)

The VOYAGE trial will assess diabetic retinopathy severity scale (DRSS) levels, through 112 weeks, while being managed with aflibercept as needed, among subjects who completed the 2-year PANORAMA trial (VGFTe-OD-1411) and were treated in a clinical setting prior to joining the VOYAGE study.

aflibercept injection
  • 26 Mar, 2022
  • 9 locations
Safety and Efficacy of rAAV.hCNGA3 Gene Therapy in Patients With CNGA3-linked Achromatopsia

The purpose of this study is to proof the safety and efficacy of a single bilateral subretinal injection of rAAV.hCNGA3 in adult and minor patients with CNGA3-linked achromatopsia.

  • 10 Apr, 2021
  • 1 location
A Phase 2 Randomized, Placebo-controlled, Double-masked Proof-of-concept Study to Investigate the Efficacy and Safety of Runcaciguat (BAY 1101042) in Patients With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NEON-NPDR)

7-field color fundus photography for central assessment of the diabetic retinopathy severity score, or DRSS. Two-step DRSS improvement at 24 weeks of treatment will be the primary efficacy endpoint

proliferative diabetic retinopathy
fundus photography
background diabetic retinopathy
severe nonproliferative diabetic retinopathy
  • 16 Oct, 2022
  • 13 locations
Village-Integrated Eye Worker Trial II (VIEW II)

aberrations due to cataract than is fundus photography. OCT machines have pre-installed algorithms to screen for glaucoma, and major anatomical abnormalities can easily be detected even by novice technicians

Accepts healthy volunteers
brimonidine tartrate ophthalmic solution
visual impairment
refractive error
  • 10 Feb, 2022
  • 1 location
Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.

Accepts healthy volunteers
  • 14 Nov, 2021
  • 1 location
To Evaluate the Effectiveness of New Specially Designed Fitlens Soft Lens.

Myopia is a common disorder, affecting approximately one-third of the US population and over 90% of the population in some East Asian countries. High amounts of myopia are associated with an increased risk of sight-threatening problems, such as retinal detachment, choroidal degeneration, cataracts, and glaucoma. Slowing the progression of myopia …

Accepts healthy volunteers
contact lens prescription
subjective refraction
  • 07 Jul, 2022
  • 1 location
Oral Metformin for Treatment of ABCA4 Retinopathy

Background ABCA4 retinopathy is a genetic disease in which the ABCA4 protein is absent or faulty. It can cause waste material to collect in the eye and may cause cells to die. The cell death can lead to vision loss. Researchers want to see if an oral drug called metformin …

  • 04 Oct, 2022
  • 1 location
Retinal Ischemia Characterization in Diabetes. (RICHARD)

Retinal ischemia characterization in diabetes - RICHARD

  • 25 Oct, 2022
  • 1 location
Wenzhou Dry Age-related Macular Degeneration (AMD) Progression Study

To evaluate the correlation between macular pigment optical density (MPOD) levels and risk of progression in patients with age-related macular degeneration

  • 12 Feb, 2022
  • 1 location
High Resolution Retinal Imaging in Patients With Inherited Retinal Degenerations

The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).

Accepts healthy volunteers
retinal degeneration
  • 24 Oct, 2022
  • 1 location