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Found 272 clinical trials
Development of a Novel Transdiagnostic Intervention for Anhedonia - R33 Phase

The overall goal of this project is to develop a novel transdiagnostic treatment for anhedonia, called Behavioral Activation Treatment for Anhedonia (BATA), using ultra-high field functional neuroimaging. There is a critical need for a validated treatment that specifically targets anhedonia, and this project will evaluate the effects of this new …

  • 25 Jan, 2021
  • 1 location
Augmented Mindfulness Training for Resilience in Early Life

This project aims to determine whether neurofeedback augmented mindfulness intervention increases the plasticity in brain areas affected by exposure to early life adversity in youth. The study will first establish the augmented mindfulness training protocol targeting the posterior cingulate cortex (PCC) with real-time fMRI neurofeedback for use with healthy control …

  • 19 Jun, 2021
  • 1 location
Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease

Interventions that affect many different aspects of human ability rather than just one aspect of human health are more likely to be successful in preventing and treating Alzheimer's disease (AD). Functional decline in AD is severely impacted by impaired ability to do physical actions while having to make decisions and …

  • 02 Feb, 2021
  • 1 location
Treating Hyperexcitability in AD With Levetiracetam

The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic medication levetiracetam (LEV) normalizes these measures and improves cognition.

positron emission tomography
mini-mental state examination
  • 25 Jan, 2021
  • 1 location
COG-REAGENT: COGnitive tRaining in patiEnts With Amnestic Mild coGnitive impairmENT

This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with amnestic mild cognitive impairment (aMCI). Half of participants will receive multi-domain adaptive internet-based training program, while the other half will receive a fixed, primary difficulty level task.

  • 16 Apr, 2021
  • 1 location
Serotonergic Modulation of Cognition Emotion and Brain Activation in Healthy Volunteers

The aim of this project is: To apply a pharmacological tool of selective serotonin (5-hydroxytryptamine, 5-HT system) reuptake inhibition in healthy humans. Specifically: To investigate how sub-chronic administration of 20 mg of escitalopram affects cognitive performance ('cold' cognition) and social-emotional functioning ('hot' cognition) compared with placebo; and To investigate how …

  • 25 Jan, 2021
  • 1 location
The Nicotinic Cholinergic System and Cognitive Aging

Prior research has shown that a chemical system in the brain called the cholinergic system is primarily responsible for cognitive symptoms seen in people with dementia. While therapeutic benefits are clear in dementia, what remains uncertain is the role that the cholinergic system in general and a subset of receptors …

  • 10 May, 2021
  • 1 location
Compressed Intermittent Theta Burst Stimulation

In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy …

  • 12 Mar, 2021
  • 1 location
Reward Circuit Modulation Via fMRI-informed-EEG-based Musical Neurofeedback

The goal of this study is to test whether voluntary up-regulation of mesolimbic reward system activation is possible, and to examine the neurobehavioral effects of specific neuromodulation of this circuit on reward processing. This goal will be achieved by testing the effects of a novel non-invasive experimental framework for neuromodulation …

  • 15 May, 2021
  • 1 location
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis

Parkinson's disease is often characterised by movement symptoms such as rigidity and bradykinesia, however, there are a number of non-motor symptoms that can have a significant impact on quality of life. One of the most common non-motor symptoms of Parkinson's disease is visual hallucinations (where someone sees things that don't …

  • 24 Jan, 2021
  • 1 location