Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 281 clinical trials
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder

This investigation will preliminarily determine if a course of high frequency rTMS applied to the left dorsolateral prefrontal cortex, will reduce cue elicited craving, and cue reactivity in treatment seeking cannabis use disordered participants.

  • 42 views
  • 10 May, 2022
  • 1 location
The Causal Connection Between Sng and Muscle Acidosis

This proposed study suggests that peripheral tissue acidosis sensed by the somatosensory system (sngceptin) would evoke the sng perception in the brain. This hypothesis is based on investigators preliminary data that the peripheral muscle acidosis will evoked the central sng perception. This proposed study also identify the detection of brain …

Accepts healthy volunteers
  • 0 views
  • 14 Feb, 2022
  • 1 location
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall aim is to establish neuroimaging biomarkers of the Dopamine Receptor 1/Dopamine Receptor 5 Family (D1R/D5R) target engagement to accelerate development of D1R/D5R agonists …

  • 24 views
  • 24 Jul, 2021
  • 4 locations
The Role of Stress Neuromodulators in Decision Making Under Risk (Part II) (SID2)

The aim of the proposed project is to combine precise pharmacological manipulation of the noradrenergic system with behavioral modeling of memory processes, and fMRI methods to study the effect of a pharmacologically induced blockade of the noradrenergic system on memory processes. Behaviorally, the investigators will focus on the effect of …

Accepts healthy volunteers
  • 0 views
  • 27 Apr, 2022
  • 1 location
Development of a Novel Transdiagnostic Intervention for Anhedonia - R33 Phase

The overall goal of this project is to develop a novel transdiagnostic treatment for anhedonia, called Behavioral Activation Treatment for Anhedonia (BATA), using ultra-high field functional neuroimaging. There is a critical need for a validated treatment that specifically targets anhedonia, and this project will evaluate the effects of this new …

  • 10 views
  • 14 Feb, 2022
  • 1 location
Augmented Mindfulness Training for Resilience in Early Life (A-MindREaL)

This project aims to determine whether neurofeedback augmented mindfulness intervention increases the plasticity in brain areas affected by exposure to early life adversity in youth. The study will first establish the augmented mindfulness training protocol targeting the posterior cingulate cortex (PCC) with real-time fMRI neurofeedback for use with healthy control …

Accepts healthy volunteers
  • 90 views
  • 15 Feb, 2022
  • 1 location
Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease

Interventions that affect many different aspects of human ability rather than just one aspect of human health are more likely to be successful in preventing and treating Alzheimer's disease (AD). Functional decline in AD is severely impacted by impaired ability to do physical actions while having to make decisions and …

  • 16 views
  • 05 Apr, 2022
  • 1 location
fMRI in Postural Tachycardia Syndrome (POTS)

Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most under appreciated …

Accepts healthy volunteers
  • 2 views
  • 13 Jun, 2022
  • 1 location
COG-REAGENT: COGnitive tRaining in patiEnts With Amnestic Mild coGnitive impairmENT

This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with amnestic mild cognitive impairment (aMCI). Half of participants will receive multi-domain adaptive internet-based training program, while the other half will receive a fixed, primary difficulty level task.

  • 0 views
  • 16 Apr, 2021
  • 1 location
Modulating Prospective Memory in Older Adults With Non-invasive Brain Stimulation

Prospective memory is the ability to remember to carry out intentions with a certain delay (e.g. remember to buy stamps when passing a postal office). Prospective memory tasks require a large degree of self-initiated retrieval and in the absence of a prompt to recall, people must 'remember to remember' by …

  • 0 views
  • 10 Jul, 2021
  • 1 location