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Found 285 clinical trials
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence

functional magnetic resonance imaging (MRI) scan. Participants will lie on a table in a metal cylinder with a coil over their head. In the first scanning session, they will see pictures, do a simple task

functional magnetic resonance imaging
Accepts healthy volunteers
alcohol withdrawal syndrome
psychological stress
  • 29 Jun, 2022
  • 1 location
Computational Psychiatric Approach to Depression

The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression. Subjects will be invited to be in this study because (1) he/she is a patient about to receive ECT treatment for depression, or (2) he/she is a healthy adult volunteer …

depressed mood
depressive symptoms
Accepts healthy volunteers
  • 07 Nov, 2021
  • 1 location
Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury

This grant award entitled, "Cerebrovascular Reactivity and Oxygen Metabolism as Markers for Neurodegeneration after Traumatic Brain Injury" (hereafter, "Neurovascular Study"), aims to determine if neurovascular contributors to neurodegeneration can serve as markers of the emergence or progression of degenerative processes after traumatic brain injury in middle-aged and older adults.

Accepts healthy volunteers
  • 10 May, 2022
  • 1 location
The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately controlled. Asthma prevalence rates have increased in the past decade, affecting 8.4% (25.7 million people) of the United States …

airways disease
  • 01 Sep, 2021
  • 2 locations
Stress and Brain Response Using MEG in PWS

Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges. In addition, some patients with PW been shown to have low cortisol production, particularly in stressful situations. However, research examining how hormonal, cognitive, and psychological factors are interrelated PWS is limited. To …

Accepts healthy volunteers
  • 13 Feb, 2022
  • 1 location
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of …

  • 22 Apr, 2022
  • 1 location
Strength Aging and Memory in Prostate Cancer

The objective of this study is to compare changes in neurocognitive function across a 12-month period between three groups: (1) men treated with androgen deprivation therapy (ADT) for prostate cancer (PCa); (2) men under active surveillance for PCa; and (3) men without a history of cancer.

Accepts healthy volunteers
  • 27 Oct, 2021
  • 1 location
Neural Correlates of Social Touch and Interoceptive Perception as Potential Biomarker for Impaired Social Functioning

Recent studies have shown that certain biomarkers of schizophrenia could help to better assess the individual course of the disease and thus, contribute to more personalized treatment options. The aim of the SPIRIT study is to identify potential biomarkers for the prediction of disease-associated outcomes by investigating the neurobiological mechanisms …

Accepts healthy volunteers
  • 05 Oct, 2021
  • 1 location
Comparing Neural Responses to Food Images in EDNOS Patients and Healthy Controls Using fMRI

Currently, there is not a robust, testable neural model available that sufficiently explains the development and maintenance of anorexia nervosa (AN) a severe, often fatal, adolescent-onset eating disorder. Using state of the art neuroimaging and neuropsychological techniques, our objective is to identify neural mechanisms in the adolescent brain underlying AN. …

  • 08 May, 2021
  • 2 locations
Striatal Connectivity and Clinical Outcome in Psychosis

This is an observational neuroimaging treatment study. This study involves examining the neural circuitry of controlled treatment of patients presenting with a first-episode of psychosis with risperidone or aripiprazole. Patients who present for treatment of a first psychotic episode with a schizophrenia spectrum diagnosis and who are eligible to undergo …

mood disorder
Accepts healthy volunteers
brief psychotic disorder
  • 25 Mar, 2022
  • 1 location