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Found 272 clinical trials
Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury

This grant award entitled, "Cerebrovascular Reactivity and Oxygen Metabolism as Markers for Neurodegeneration after Traumatic Brain Injury" (hereafter, "Neurovascular Study"), aims to determine if neurovascular contributors to neurodegeneration can serve as markers of the emergence or progression of degenerative processes after traumatic brain injury in middle-aged and older adults.

Accepts healthy volunteers
  • 10 May, 2022
  • 1 location
Chronic Stress, Cognition, and Food Cue Reactivity in Prader-Willi Syndrome: A Magnetoencephalography Study

Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges. In addition, some patients with PW been shown to have low cortisol production, particularly in stressful situations. However, research examining how hormonal, cognitive, and psychological factors are interrelated PWS is limited. To …

Accepts healthy volunteers
  • 17 Sep, 2022
  • 1 location
The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately controlled. Asthma prevalence rates have increased in the past decade, affecting 8.4% (25.7 million people) of the United States …

Accepts healthy volunteers
airways disease
  • 21 Sep, 2022
  • 2 locations
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of …

depressive disorder
transcranial magnetic stimulation
  • 22 Apr, 2022
  • 1 location
Comparing Neural Responses to Food Images in EDNOS Patients and Healthy Controls Using fMRI

Currently, there is not a robust, testable neural model available that sufficiently explains the development and maintenance of anorexia nervosa (AN) a severe, often fatal, adolescent-onset eating disorder. Using state of the art neuroimaging and neuropsychological techniques, our objective is to identify neural mechanisms in the adolescent brain underlying AN. …

  • 08 May, 2021
  • 2 locations
Neural Correlates of Social Touch and Interoceptive Perception as Potential Biomarker for Impaired Social Functioning

Recent studies have shown that certain biomarkers of schizophrenia could help to better assess the individual course of the disease and thus, contribute to more personalized treatment options. The aim of the SPIRIT study is to identify potential biomarkers for the prediction of disease-associated outcomes by investigating the neurobiological mechanisms …

Accepts healthy volunteers
  • 05 Oct, 2021
  • 1 location
Social Integration During Psychiatric Inpatient Therapy as Predictor of Treatment Response

The present longitudinal study aims at (i) identifying neurobiological mechanisms associated with successful social integration during the treatment of inpatients with Borderline Personality Disorder (BPD) and (ii) improving biomarker-based predictions of treatment response by incorporating core metrics of social integration.

behavior therapy
Accepts healthy volunteers
  • 16 Oct, 2021
  • 1 location
Striatal Connectivity and Clinical Outcome in Psychosis

This is an observational neuroimaging treatment study. This study involves examining the neural circuitry of controlled treatment of patients presenting with a first-episode of psychosis with risperidone or aripiprazole. Patients who present for treatment of a first psychotic episode with a schizophrenia spectrum diagnosis and who are eligible to undergo …

structured clinical interview
mood disorder
psychotic episode
  • 25 Mar, 2022
  • 1 location
Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease

A number of studies from the literature suggest important behavioral, psychosocial, or radiologic changes occur following significant neurologic events or interventions such as stroke, neurosurgery, medications, radiation, systemic therapy, or injury. The purpose of this study is to describe these changes with advanced neurologic imaging and targeted neurologic and neuropsychiatric …

depression screening
depressed mood
  • 11 May, 2022
  • 1 location
Detection and Characterization of Residual Masses in Lymphomas (ADAMANTIUS)

The present study aims to further optimize a whole-body Diffusion-Weighted Magnetic Resonance Imagery (DW-MRI or DWI) protocol on 3 Tesla MR and/or new system combining 3Tesla MR and Positron Emission Tomography (PET), to develop and validate an automated whole-body parametric image analysis algorithm, and to determine the added value of …

follicular lymphoma
diffuse lymphoma
hodgkin's disease
diffuse large b-cell lymphoma
  • 30 Apr, 2022
  • 2 locations