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Found 233 clinical trials
Effects of Transcranial Direct Current Stimulation (tDCS) on Language

This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.

transcranial direct current stimulation
deficit
electrical stimulation
speech therapy
stroke
  • 1 views
  • 01 May, 2022
  • 1 location
Semantic Feature Analysis Treatment for Aphasia

This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic …

brain imaging
treatment schedule
migraine
functional brain imaging
stroke
  • 0 views
  • 22 Mar, 2022
  • 1 location
Sex Differences in Risk for Alcohol Abuse

This study will determine the neural and hormonal mechanisms underlying sex differences in sensitivity to the disinhibiting effects of alcohol in heavy drinkers.

Accepts healthy volunteers
  • 0 views
  • 03 Jun, 2022
  • 1 location
Escitalopram and Language Intervention for Subacute Aphasia (ELISA)

In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).

  • 0 views
  • 11 May, 2022
  • 3 locations
Enhancing Brain Health by tDCS in Persons With Overweight and Obesity (STIM)

Disturbances in the hypothalamus communication pathways with other regions in the brain and the periphery may represent a potential link between metabolic and cognitive health. The current project evaluates whether enhancing synaptic plasticity of this pathway can improve weight management, insulin sensitivity, and cognitive functions. In recent studies, we were …

weight control
insulin
Accepts healthy volunteers
diabetes
overweight and obesity
  • 8 views
  • 22 Mar, 2022
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use

Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis abstinence in people with psychosis and non-psychiatric controls with cannabis use. Participants will be randomized to a cannabis abstinent …

cognitive impairment
Accepts healthy volunteers
cannabis use
  • 0 views
  • 04 Oct, 2022
  • 1 location
Gamma Induction for Amyloid Clearance in Alzheimer's Disease

Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) plaque buildup and phosphorylated tau (p-tau) in the brain, as well as widespread neurodegeneration. Amyloid-β and tau are proteins that build up in the brain that may contribute to memory problems. The evidence suggests that both amyloid and tau play a critical …

cholinesterase
amyloidosis
memory loss
dementia
rivastigmine
  • 23 views
  • 23 Oct, 2022
  • 1 location
Enhancing Language Function in Primary Progressive Aphasia (PPA)

This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around …

  • 0 views
  • 12 Jul, 2022
  • 1 location
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the …

brain stimulation
medication regimen
  • 0 views
  • 26 Apr, 2022
  • 1 location
Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits

This study is designed to determine whether bupropion (vs escitalopram) increases functional connectivity (FC) within reward-related neurocircuits and decreases motivational deficits in depressed patients with increased inflammation and anhedonia. Participants will be randomized to take bupropion extended release (XL) or escitalopram for 8 weeks.

scid
psychotropic drugs
citalopram
structured clinical interview
fluoxetine
  • 0 views
  • 24 Mar, 2022
  • 1 location