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Found 233 clinical trials
The Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Background People who binge drink are more likely to have risky sexual encounters, and alcohol changes brain activity associated with reward decisions related to those behaviors. Researchers want to better understand how alcohol s effects on risky sexual behavior that might lead people to contract sexually transmitted diseases (STDs) like …

Accepts healthy volunteers
  • 22 Oct, 2022
  • 1 location
The Efficacy and Neurobehavioural Mechanism of Cannabidiol (CBD) for Alcohol Dependence

The study will explore the psychophysiological and neurobiological and mechanisms of CBD in participants with alcohol use disorder

  • 14 Jun, 2022
  • 1 location
A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device

The purpose of this research is to determine if two non-invasive brain stimulation techniques, muscle stimulation of the arm and neuro-stimulation through the tongue, can increase the extent of stroke recovery.

electrical stimulation
stroke rehabilitation
Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Understanding the Acute Modulation of Brain Activity by Transcranial Magnetic Stimulation

Background Transcranial magnetic stimulation (TMS) is form of non-invasive brain stimulation. It is approved to treat depression. TMS may help decrease drug craving. It is important to understand how TMS affects the brain. Such a better understanding would help to design ways to treat drug addiction. Objectives To learn how …

Accepts healthy volunteers
  • 10 Oct, 2022
  • 1 location
A Prospective, Randomized, Open Label, Parallel, 12-month Study to Explore and Evaluate the Therapeutic Effects ofLiraglutide, Empagliflozin and Linagliptin on the Cognitive Function, Olfactory Function, and Odor-induced Brain Activation in T2DM Patients With Mild Cognitive Impairment.

This is a prospective, randomized, open label, parallel, 12-month study to explore and evaluate the therapeutic effects of Liraglutide, Empagliflozin and Linagliptin on the cognitive function, olfactory function, and odor-induced brain activation in T2DM patients with mild cognitive impairment(MCI).

hemoglobin a1c
type 2 diabetes mellitus
  • 21 Oct, 2022
  • 3 locations
Neuroimaging Biomarkers for Predicting rTMS Response in OCD

This study evaluates an accelerated schedule of theta-burst stimulation using a Transcranial Magnetic Stimulation (TMS) device for treatment-resistant Obsessive Compulsive Disorder (OCD). In a randomized fashion, half the participants will receive accelerated theta-burst stimulation at the dorsomedial prefrontal cortex (DMPFC), while half will receive accelerated theta-burst stimulation at the right …

behavior therapy
Accepts healthy volunteers
  • 24 Mar, 2022
  • 1 location
Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

This phase I trial finds out the best dose, possible benefits and/or side effects of papaverine when given together with chemoradiation intreating patients with stage II-III non-small cell lung cancer. Papaverine targets mitochondrial metabolism to decrease the cancer growth process. Giving papaverine with chemoradiation may work best to treat patients …

  • 11 May, 2022
  • 1 location
Explosive Synchronization of Brain Network Activity in Chronic Pain

This project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization …

functional magnetic resonance imaging
chronic pain
Accepts healthy volunteers
  • 15 Oct, 2022
  • 1 location
Treating Hyperexcitability in AD With Levetiracetam (LeAD)

The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic medication levetiracetam (LEV) normalizes these measures and improves cognition.

Accepts healthy volunteers
mental state examination
speech therapy
mini-mental state examination
  • 25 Jan, 2022
  • 1 location
Functional Brain Mechanisms Underlying the Anti-Suicidal Effects of Low-dose Buprenorphine in Major Depression

This study aims to examine the effect of low-dose buprenorphine as an add-on to treatment-as-usual for suicidal ideation in individuals with major depression, and investigate the functional brain activity related to its potential anti-suicidal effect.

depressed mood
  • 23 Oct, 2022
  • 1 location