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Found 44 clinical trials
EEG and TMS-based Biomarkers of ALS, MS and FTD

The purpose of this observational study is to improve understanding of the biology of why ALS, MS and FTD have different effects on different people and facilitate better measurement of the disease in future drug testing. To do this, brain and spinal cord neural network functionality will be measured over …

semantic dementia
disease or disorder
dementia
frontotemporal dementia
Accepts healthy volunteers
  • 5 views
  • 25 Jan, 2022
  • 1 location
Featured trial
Alzheimer’s Disease Research Center (ADRC) Longitudinal Study

This study is looking for people with mild cognitive impairment, young-onset Alzheimer’s, frontotemporal dementia, or Lewy body dementia. The study is also looking for cognitively-normal people over the age of 65, as a comparison. The study will follow the progression of various dementias to help with early detection, accurate diagnosis, …

dementia, frontotemporal
stroke
dementia
Accepts healthy volunteers
depression
  • 218 views
  • 25 Jan, 2022
  • 1 location
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases

Tau protein has been identified as one of the key pathological features of Tau proteinopathies, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD). Tau protein-targeted PET imaging can detect the amount and distribution of Tau protein deposition in human body, and has great research and application …

dementia, frontotemporal
dementia
Accepts healthy volunteers
screening procedures
tau protein
  • 0 views
  • 14 Mar, 2022
  • 1 location
A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy

This trial is designed primarily to generate safety, tolerability, and pharmacodynamic data for further clinical development of CVL-871 in a subject population with dementia-related apathy.

apathy
dementia
  • 9 views
  • 31 May, 2022
  • 1 location
Featured trial
Late Onset Alzheimer's Disease Study (LOAD)

This study is looking for people who have Alzheimer’s or a related dementia, and also have family members who have Alzheimer’s. The study is interested in the genetics of Alzheimer’s risk.

Accepts healthy volunteers
dementia
Online studies
  • 2313 views
  • 30 Sep, 2022
  • 1 location
  • Online study
Validation of Serum Neurofilament Light Chain as a Biomarker to Differentiate Cognitive Impairment From Neurodegenerative or Psychiatric Diseases (Nfl_COG)

The validation of biomarkers allowing the discrimination of cognitive and behavioral disorders of psychiatric origin from those of neurodegenerative origin would facilitate diagnosis and improve patient management. Neurofilaments, which are markers of neuronal lysis, appear to be a promising biomarker. In a previous preliminary study, the investigators demonstrated significantly lower …

bipolar disorder
schizophrenia
cognitive impairment
alzheimer's disease
  • 0 views
  • 21 Oct, 2022
  • 2 locations
Featured trial
Decisions Around Dementia and Surgery (DecADES)

We are conducting a research study to better understand the experiences of persons living with dementia or memory problems and their care companions when making decisions about surgery. We seek patients and/or care companions of persons with dementia who have either: 1) had a surgery within the past year or …

dementia
cognitive impairment
Online studies
Accepts healthy volunteers
alzheimer's disease
  • 68 views
  • 15 Nov, 2022
  • 1 location
  • Online study
The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech (SLD4T)

The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.

cognitive assessment
  • 72 views
  • 19 Apr, 2022
  • 1 location
Phenotype, Genotype and Biomarkers 2 (PGB2)

The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist …

dementia
frontotemporal dementia
Accepts healthy volunteers
hereditary spastic paraplegia
primary lateral sclerosis
  • 0 views
  • 10 Jul, 2022
  • 4 locations
WeCareAdvisor Study for Caregivers of People Living With Dementia

The WeCareAdvisor is an online tool to help caregivers manage behavioral and psychological symptoms of people living with dementia. The trial will evaluate its efficacy to reduce caregiver distress, improve confidence managing behaviors, as well as reduce occurrences and severity of behavioral and psychological symptoms. Visit https://wecareadvisorstudy.com/ for more information.

psychotropic
dementia
Accepts healthy volunteers
psychological symptoms
depression
  • 0 views
  • 23 Mar, 2022
  • 1 location