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Found 44 clinical trials
Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Trial (PEA-FTD)

Frontotemporal dementia (FTD) is a devastating neurodegenerative disorder. It is the second most frequent cause of presenile neurodegenerative dementia in those less than 65 years of age. Currently, there is no effective pharmacological treatment to slow down the progression of FTD. Recently, it has been proposed that neuroinflammation could be …

amyotrophic lateral sclerosis
alzheimer's disease
amyloid
acetylcholinesterase inhibitor
neurodegenerative disorders
  • 0 views
  • 15 Jul, 2022
  • 2 locations
Tanycytes in Alzheimer's Disease and Frontotemporal Dementia (BIOWATCH)

Metabolic and hormonal deregulations are both a risk factor and a hallmark of Alzheimer's disease (AD) and frontotemporal dementia (FTD), occurring early in the course of the disease. In FTD in particular, hyperorality and dietary changes are associated with metabolic and hormonal changes such as altered levels of the anorexigenic …

alzheimer's disease
dementia
mini-mental state examination
dementia, frontotemporal
cognitive impairment
  • 0 views
  • 25 Apr, 2022
Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions

The overall objective of this study is to compare knowledge, decisional conflict, preferences, and caregiver burden over time caregivers of Alzheimer's Disease and Related Dementias (ADRD) patients by comparing the effectiveness of a video decision aid intervention and enhanced usual care.

Accepts healthy volunteers
dementia
dementia, frontotemporal
alzheimer's disease
  • 0 views
  • 05 Jun, 2022
  • 1 location
Better Living With Non-memory-led Dementia

This is a feasibility study on the effects of an online-based training and education programme for carers of people with posterior cortical atrophy (PCA), primary progressive aphasia (PPA) and behavioural-variant frontotemporal dementia (bvFTD).

Accepts healthy volunteers
dementia
dementia, frontotemporal
aphasia
  • 0 views
  • 07 Oct, 2022
  • 1 location
Featured trial
Genetics in Alzheimer Disease Related Dementias

The Alzheimer Disease Related Dementia studies are looking for participants to better understand the genetic factors contributing to frontotemporal dementia or dementia with Lewy bodies. Genetics helps us improve the knowledge on biology, diagnosis and future therapies for these diseases.

Accepts healthy volunteers
Online studies
  • 1144 views
  • 23 Sep, 2022
  • 1 location
  • Online study
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

The investigators are researching families with inherited inclusion body myopathy (IBM) and/or Paget disease of bone (PDB) and/or dementia (FTD) which is also called IBMPFD. IBMPFD is caused by mutations in the VCP gene. Our main goal is to understand how changes in the VCP gene cause the muscle, bone …

amyotrophic lateral sclerosis
bone fibrous dysplasia
diaphyseal medullary stenosis with malignant fibrous histiocytoma
bone disease
paget's disease of bone
  • 58 views
  • 25 Jan, 2022
  • 1 location
Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD) (FOCUS-C9)

This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of intrathecal (IT) WVE-004 in adult patients with C9orf72-associated ALS or FTD. To participate in the study, patients must have a documented mutation (GGGGCC [G4C2] repeat expansion) in the first intronic region …

amyotrophic lateral sclerosis
dementia
frontotemporal lobar degeneration
frontotemporal dementia
riluzole
  • 1 views
  • 07 Oct, 2022
  • 17 locations
tDCS Intervention in Primary Progressive Aphasia

Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. Mild cognitive impairment (MCI) is slowly progressive decline in a single domain of cognition (e.g. language) not attributable to motor or sensory loss, without impediment of social or occupational function. MCI can be an early …

alzheimer's disease
cognitive impairment
neurodegenerative disorders
neuropsychological test
neuropsychological assessment
  • 7 views
  • 15 Jul, 2022
  • 1 location
Featured trial
New Approaches to Dementia Heterogeneity.

This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …

amyotrophic lateral sclerosis
multiple sclerosis
cognitive impairment
depression
heart disease
  • 160 views
  • 25 May, 2021
  • 1 location
A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

This is a Phase 2a study to assess the the safety and tolerability of TPN-101 in patients with Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) Associated with Hexanucleotide Repeat Expansion in the C9orf72 gene (C9ORF72 ALS/FTD).

amyotrophic lateral sclerosis
mini-mental state examination
cognitive impairment
weakness
primary lateral sclerosis
  • 2 views
  • 01 May, 2022
  • 18 locations