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Found 44 clinical trials
Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia (Lithium)

Frontotemporal dementia (FTD) is a progressive neurodegenerative illness that affects the frontal and anterior temporal lobes of the brain. Changes in behavior, including agitation, aggression, and repetitive behaviors, are common symptoms in FTD. The investigators currently do not have good medications to treat these symptoms in FTD, and the medications …

aphasia
mental state exam
mini-mental state examination
placebo pill
  • 109 views
  • 24 Feb, 2022
  • 1 location
Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias

Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders. This study will use hybrid PET/MRI imaging to evaluate neuroinflammation and its relationship to cerebral perfusion in frontotemporal dementia (FTD). Patients with FTD will be recruited from the Cognitive Neurology and Aging …

Accepts healthy volunteers
psychiatric disorders
positron emission tomography
neuropsychological assessment
dementia
  • 50 views
  • 24 Feb, 2022
  • 1 location
Non-invasive Brain Stimulation for Gamma-induction and Cognitive Enhancement in FTD (Gamma-Induction in FrontoTemporal Dementia, GIFTeD) (GIFTeD)

This is an interventional, sham controlled, double-blind study designed to investigate the safety, tolerability and efficacy of 40 Hz transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation, delivered for 6 weeks once daily in frontotemporal dementia (FTD) patients. Cognition, gamma EEG activity and brain metabolism via FDG-PET …

mini-mental state examination
frontotemporal lobar degeneration
18f-fdg
antipsychotic agents
memantine
  • 26 views
  • 20 Oct, 2022
  • 2 locations
GENetic Fronto Temporal Dementia Initiative in Lille (GENFI-LILLE)

GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families with a known mutation in GRN or MAPT or an expansion in C9orf72 (including those affected with …

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
Phase 1/2 Clinical Trial of PR006 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) (PROCLAIM)

Study PRV-FTD101 is a Phase 1/2, multi-center, open-label ascending dose, first-in-human study that will evaluate the safety and effect of intra-cisternal PR006 administration on progranulin protein (PGRN) levels in patients with frontotemporal dementia with progranulin mutations (FTD-GRN). Three escalating dose (low dose, medium dose and high dose) cohorts are planned. …

mycobacterium tuberculosis
progranulin
dementia
serum pregnancy test
  • 26 views
  • 04 Oct, 2022
  • 7 locations
Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Trial (PEA-FTD)

Frontotemporal dementia (FTD) is a devastating neurodegenerative disorder. It is the second most frequent cause of presenile neurodegenerative dementia in those less than 65 years of age. Currently, there is no effective pharmacological treatment to slow down the progression of FTD. Recently, it has been proposed that neuroinflammation could be …

amyloid
palmitoylethanolamide
amyotrophic lateral sclerosis
luteoline
alzheimer's disease
  • 0 views
  • 15 Jul, 2022
  • 2 locations
Intranasal Oxytocin for Frontotemporal Dementia (FOXY)

The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no medication) in participants with frontotemporal dementia/Pick's disease. This study will take place in approximately 15 …

brain mri
dementia
frontotemporal lobar degeneration
mini-mental state examination
antipsychotic agents
  • 127 views
  • 04 Mar, 2022
  • 11 locations
A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment

The primary objective is to assess the safety and tolerability of Metformin in subjects with C9orf72 amyotrophic lateral sclerosis administered for 24 weeks. The overall objective is to determine if Metformin is safe in C9orf72 ALS patients and is a potentially viable therapeutic treatment for C9-ALS that reduces repeat-associated non-canonical …

metformin
amyotrophic lateral sclerosis
  • 70 views
  • 10 Oct, 2022
  • 1 location
A Study of PBFT02 in Patients With Frontotemporal Dementia and Progranulin Mutations (FTD-GRN) (upliFT-D)

PBFT02 is a gene therapy for frontotemporal dementia intended to deliver a functional copy of the GRN gene to the brain. This study will assess the safety, tolerability and efficacy of this treatment in patients with frontotemporal dementia and mutations in the progranulin gene (FTD-GRN).

progranulin
  • 1 views
  • 11 May, 2022
  • 3 locations
Epidemiological Study in FRONtoTemporal Dementia (EFRONT)

An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.

Accepts healthy volunteers
genetic testing
  • 0 views
  • 04 Oct, 2022
  • 28 locations