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Found 42 clinical trials
The Swedish BioFINDER 2 Study (BioFINDER2)

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

Accepts healthy volunteers
cancer
cognitive decline
brain imaging
mini-mental state examination
  • 178 views
  • 25 Feb, 2022
  • 1 location
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology (Veri-T-001)

The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar

  • 0 views
  • 27 Apr, 2022
  • 1 location
Treatment for Speech and Language in Primary Progressive Aphasia

Primary progressive aphasia (PPA) is a progressive neurological disorder that causes a gradual decline in communication ability as a result of selective neurodegeneration of speech and language networks in the brain. PPA is a devastating condition affecting adults as young as their 40's or 50's, depriving them of the ability …

mental state examination
mini-mental state examination
Accepts healthy volunteers
  • 0 views
  • 14 Apr, 2022
  • 2 locations
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through

Accepts healthy volunteers
progressive supranuclear palsy
corticobasal degeneration
dementia, frontotemporal
dementia
  • 236 views
  • 28 May, 2022
  • 23 locations
UPenn Observational Research Repository on Neurodegenerative Disease (UNICORN)

The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.

atrophy
Accepts healthy volunteers
progressive supranuclear palsy
dementia, frontotemporal
frontotemporal lobar degeneration
  • 1 views
  • 04 Oct, 2022
  • 1 location
Neurofilament Surveillance Project (NSP)

This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control

frontotemporal lobar degeneration
Accepts healthy volunteers
  • 12 views
  • 24 Mar, 2022
  • 7 locations
Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease (META-DEM)

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

dementia
mini-mental state examination
Accepts healthy volunteers
alzheimer's disease
  • 0 views
  • 24 May, 2022
  • 6 locations
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Background Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells. Researchers want to understand whether these diseases have related causes or risk factors. Objective To test people with movement or thinking and memory problems to see if they …

dementia, frontotemporal
genetic testing
dementia
frontotemporal lobar degeneration
blood tests
  • 61 views
  • 04 Oct, 2022
  • 1 location
A Phase 3, Multicenter, Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of AL001 in Individuals at Risk for or With Frontotemporal Dementia Due to Heterozygous Mutations in the Progranulin Gene

A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.

aphasia
dementia
progranulin
  • 29 views
  • 19 Sep, 2022
  • 45 locations
Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Trial (PEA-FTD)

Frontotemporal dementia (FTD) is a devastating neurodegenerative disorder. It is the second most frequent cause of presenile neurodegenerative dementia in those less than 65 years of age. Currently, there is no effective pharmacological treatment to slow down the progression of FTD. Recently, it has been proposed that neuroinflammation could be …

luteoline
dementia
amyotrophic lateral sclerosis
amyloid
neurodegenerative disorders
  • 0 views
  • 15 Jul, 2022
  • 2 locations