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Found 44 clinical trials
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The Swedish BioFINDER 2 Study

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

neurodegenerative disorders
tauopathies
cancer
screening procedures
cognitive symptoms
  • 171 views
  • 11 Mar, 2021
  • 3 locations
None
Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia

Within the spectrum of fronto-temporal lobar degeneration (FTLD) semantic dementia (SD) causes profound language dysfunction. SD damages semantic processing typically in the temporal poles (anterior temporal lobes, ATL). It is an early onset disease (often before 65 years of age) affecting about 4000 patients in France and for which no …

frontotemporal lobar degeneration
multi-day
semantic dementia
stroke
  • 0 views
  • 18 Sep, 2021
  • 4 locations
None
Natural History Characterization in Symptomatic and Asymptomatic Progranuline Gene Mutation Carriers

The purpose of this study is to investigate whether cognitive deficits, structural and functional changes can be detected before symptom onset in presymptomatic progranuline mutation carriers. The main objectives of the project are to identify novel cognitive, brain imaging markers and peripheral biomarkers for early diagnosis of FTLD, and to …

dementia, frontotemporal
  • 0 views
  • 24 Jan, 2021
  • 3 locations
None
Mindfulness-Based Stress Reduction in Dementia Caregivers

Aims: The overall study will contribute to understanding how the cultivation of caregiver mindfulness might improve the quality of relationship between caregivers and demented patients by making it more mutual, connected, empathic and positive. This study will additionally elucidate which facets of mindfulness account for caregiver's happiness and psychological well-being. …

dementia
Accepts healthy volunteers
demented
  • 3 views
  • 08 Oct, 2021
  • 1 location
None
Assessment of Apathy in a Real-life Situation With a Video and Sensors-based System

Apathy can be defined as a quantitative reduction of voluntary or goal-directed behavior. So, the investigators propose a behavioral approach for assessing apathy, to obtain a quantifiable and objective signature of reduced goal-directed behavior by directly observing a patient in a real-life situation. ECOCAPTURE consists of a multi-step scenario in …

depressive disorder
impulse control disorder
parkinson's disease
dementia
psychiatric disorder
  • 88 views
  • 23 Jan, 2021
  • 1 location
None
Dopaminergic Therapy for Frontotemporal Dementia Patients

This is a phase IIa 24-week randomized, double-blind, placebo-controlled study. The study is designed to evaluate the efficacy and safety of Rotigotine (RTG) transdermal administration at the dosage of 4 mg or 6 mg per day versus Placebo (PLC) in newly diagnosed behavioural Frontotemporal Dementia (bvFTD) patients. 75 patients with …

alzheimer's disease
dementia, frontotemporal
rivastigmine
dementia
amyloid
  • 0 views
  • 13 Sep, 2021
  • 3 locations
None
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through

primary lateral sclerosis
amyotrophic lateral sclerosis
dementia, frontotemporal
dementia
frontotemporal dementia
  • 79 views
  • 10 Sep, 2021
  • 23 locations
None
UPenn Observational Research Repository on Neurodegenerative Disease

The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.

  • 0 views
  • 29 Apr, 2021
  • 1 location
None
Neurofilament Surveillance Project (NSP)

This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control

frontotemporal lobar degeneration
  • 12 views
  • 03 Jul, 2021
  • 8 locations
None
Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

  • 0 views
  • 24 Feb, 2021
  • 7 locations