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Found 9 clinical trials
Fiber Intervention on Gut Microbiota in Children With Prader-Willi Syndrome

Prader-Willi syndrome (PWS) is the most common syndromic cause of obesity. Individuals with PWS characteristically experience excessive weight gain and severe hyperphagia with food compulsivity in early childhood, which often leads to the onset of obesity and metabolic complications. The pathogenesis of hyperphagia and progressive weight gain in PWS is …

chromosome analysis
growth hormone
body mass index
  • 22 Apr, 2022
  • 1 location
The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients. (Dexa)

Glucocorticoids are well known for their analgesic, anti-inflammatory, immunomodulatory and anti-emetic effects. Recovery time after thyroid surgery may depend on several factors, such as postoperative pain, nausea and vomiting, postoperative sore throat, voice disorders and symptomatic hypocalcaemia (low serum calcium level). However, there is little information in the literature about …

parathyroid hormone
blood tests
  • 24 Mar, 2022
  • 1 location
Personalized Treatment in Thyroid Disorders

The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to provide data regarding radioiodine exposure that correlates with conventional methods of measuring …

differentiated thyroid cancer
  • 01 Feb, 2022
  • 1 location
Harmonization of Thyroid-stimulating Hormone Immunoassays Reagents (IFCC-TSH)

for free thyroxine, the investigators considered this option for TSH unlikely and developed a pragmatic approach to harmonization rather than standardization. Harmonization is important in

  • 23 May, 2022
Cardiac Markers in Depressed Patients With Coronary Heart Disease

Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and …

  • 27 Jan, 2021
  • 1 location
Glucose Brain and Microbiota

The accumulation of iron is known to affect the functions of the liver, adipose tissue and muscle. The brain is a well-known place of iron deposition, which is associated with cognitive parameters of subjects with obesity. The hypothesis is that certain parameters related to glucose metabolism (glycemic variability, the circulating …

glycosylated hemoglobin
hemoglobin a1c
bariatric surgery
  • 24 Jul, 2021
  • 1 location
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modify the composition of the gut microbiota …

continuous glucose monitoring
type 2 diabetes mellitus
  • 30 May, 2021
  • 1 location
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA). (IRONmiRNA)

The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions. There is evidence suggesting that the gut microbiota composition modulates this process. It has been proposed that microRNAs are mediators in the dialogue between the composition …

Accepts healthy volunteers
bariatric surgery
  • 16 May, 2022
  • 1 location
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.

Haematological malignancies constitute the most common neoplastic disease in child population, with acute leukemia occupying the number one spot with a percentage of 32.8%. In children, leukaemia is primarily encountered in its acute form (97%) and in the majority of the cases it is presented as Acute Lymphoblastic Leukaemia - …

Accepts healthy volunteers
lymphoid leukemia
acute leukemia
  • 04 Mar, 2022
  • 1 location