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Found 58 clinical trials
Evaluate the Therapeutic Effect of Inhaled Corticosteroid in Asthmatic Children

Inhaled corticosteroid (ICS) is considered the first line medication for asthma, however, the therapeutic effect is markedly different even in patients with almost similar clinical manifestations. Our study was designed to explore the clinical and genetic factors that may influence the effectiveness of ICS in asthmatic children.

  • 03 Mar, 2022
  • 1 location
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers (Pre-COPD Pilot)

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design suitable preventative and therapeutic strategies for …

tobacco smoke
Accepts healthy volunteers
chronic obstructive pulmonary disease
  • 19 Jun, 2022
  • 1 location
PaO2 and Lung Function After Orthopedic Surgery

Hypoxia and reduced oxygen partial pressure is commonly occurring after abdominal surgery. This study aims to investigate whether similar changes also occur after orthopedic surgery in the form of upper limb surgery. Inclusion: 60 patients undergoing orthopedic surgery in the form o knee-, hip-, shoulder- or elbow surgery. Exclusion: Dementia …

  • 15 Mar, 2022
Early Recovery After "Wedge Resection" Surgery to Remove Lung Mestastasis Secondary to Bone Cancer.

After "wedge resection" surgery, the physiotherapy programs proposed in the literature are heterogeneous and there are few data on the outcomes of such treatments in an oncological population for bone cancer. The aim of the study is to describe the early rehabilitation process after wedge resection surgery secondary to bone …

  • 21 Apr, 2022
  • 1 location
Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD (COPD-ENVIRON)

Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

endobronchial cryotherapy
lung volume reduction
pulmonary disease
  • 25 Feb, 2022
  • 1 location
Validation of the Risk Stratification Score in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and a considerable variability in the disease's natural history. Besides lung transplantation (LTx), the only available treatments are anti-fibrosing drugs, which have shown to slower the disease course. Therefore, predicting the prognosis is …

pulmonary function test
lung transplant
diffusion capacity of the lung for carbon monoxide
  • 25 Nov, 2021
  • 2 locations
Profiling Recovery of Those Discharged Into the Community With COVID-19

Currently, there are few studies that have been established that consist of a variety of established and coherent approaches that sought to profile the determinants of recovery, nor used interrogative procedures to understand lasting physical impairment. In this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress …

acute respiratory infections
  • 02 Jun, 2022
  • 1 location
Effect of Mepolizumab on Severe Eosinophilic Asthma (EMESEA)

Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab. B: A longitudinal cohort study,where the same patients once on mepolizumab treatment are followed over time (0, 4, 16 and 32 weeks). SCOPE: response to mepolizumab in severe adult eosinophilic …

Accepts healthy volunteers
  • 07 Oct, 2022
  • 2 locations