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Found 66 clinical trials
Alvelestat (MPH966) an Oral Neutrophil Elastase Inhibitor in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Background Bronchiolitis obliterans syndrome (BOS) is a complication people can experience after hematopoietic stem cell transplant. It usually affects people with chronic graft versus host disease (cGVHD). This occurs when donor stem cells attack the cells of the person who received them. BOS reduces airflow and oxygen levels in the …

  • 35 views
  • 28 May, 2021
  • 1 location
Asthma Diagnosis Verified by Lung Function

Guidelines suggests that asthma should not be treated prior to a reversibility test and/or an assessment with peak expiratory flow (PEF) unless there is a clinical urgency for the patient to be treated. Approximately one third of patients with diagnosed asthma can safely step-wise withdraw their asthma medication and diagnosis …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Exercise Induced Bronchoconstriction and Field Tests

Asthma and exercise induced bronchoconstriction (EIB) represent an important challenge for the athlete, and correct diagnosis is important as it affects health as well as performance with strict regulations concerning asthma medication. The primary objective of this study on elite athletes with symptoms of EIB, is to assess if EIB …

  • 0 views
  • 27 Jan, 2021
  • 1 location
CF Bronchodilation

It is estimated that one in every 3,600 children in Canada has cystic fibrosis (CF). CF is a genetic disease that affects the glands that produce mucus and sweat. In CF, mucus production increases and the mucus becomes thick and sticky. This can block the airways, making it difficult to …

dyspnea
fibrosis
wheezing
body mass index
bronchodilator
  • 3 views
  • 26 Jan, 2021
  • 1 location
Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care (active) vs. standard of care alone (SoC), the control group. The gammaCore (nVNS) treatments will be used acutely …

dyspnea
respiratory symptoms
respiratory symptom
acute respiratory distress
oximetry
  • 131 views
  • 19 Mar, 2021
  • 2 locations
Impact of Early Lung Physiology Viral Infections and the Microbiota on the Development and Progression of Lung Disease in Children With Cystic Fibrosis

This study collects data on microbiological factors and lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess their interaction on the lung growth and lung development of infants and children with Cystic Fibrosis (CF).

  • 0 views
  • 26 Jan, 2021
  • 1 location
Frailty In Thoracic Surgery for Esophageal Cancer

Background: In Demark we se an increasing life expectancy and an increasing incidence of esophageal cancer and gastroesophageal junction (c.esophagus), with an average age of 65 years at diagnosis time. The consequence of this is an increased number of patients in need of esophageal resection. Esophageal cancer is currently treated …

  • 0 views
  • 23 Jan, 2021
Predictive Value of Inflammatory Biomarkers and FEV1 for COPD

expiratory volume at one secondFEV1 and baseline inflammatory biomarkers in exhaled breath condensate and peripheral blood, we aim to explore the predictive model for chronic obstructive pulmonary

bronchodilator
forced expiratory volume
  • 11 views
  • 22 Jan, 2021
  • 10 locations
Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and fertility problems. At present, mutations in > 45 genes associated with PCD and mucociliary clearance disorders have …

  • 0 views
  • 07 May, 2021
  • 1 location
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants

This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors for impaired lung development and respiratory diseases.

diabetes
social interactions
  • 0 views
  • 24 Jan, 2021