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Found 66 clinical trials
Efficacy and Safety of CHF 6532 in Patients With Uncontrolled Severe Eosinophilic Asthma

The purpose of this phase III Study is to demonstrate the efficacy of at least one dose of CHF 6532 on moderate and severe asthma exacerbations rate compared to placebo.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy

Despite the increasingly common use of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies in treating CF, it is still largely unknown whether or not other chronic therapies can be safely stopped. The SIMPLIFY study is being done to test whether or not it is safe to stop taking inhaled …

tezacaftor
fibrosis
pulmozyme
cystic fibrosis transmembrane conductance regulator
forced expiratory volume
  • 55 views
  • 26 Jan, 2021
  • 74 locations
Steroid Withdrawal Intervention in Fife and Tayside

The SWIFT trial is a cluster randomised trial to determine if a patient identification, feedback and inhaled corticosteroid (ICS) withdrawal intervention in primary care can result in more appropriate inhaled corticosteroid use without increasing the frequency of exacerbations. Practices in Tayside and Fife will be randomised at practice level to …

corticosteroids
bronchodilator
muscarinic antagonists
  • 37 views
  • 17 Mar, 2021
  • 2 locations
Digital Prevention of Asthma

Asthma self-management is dependent on support and education. To facilitate self-management have we developed and CE-mark a novel digital self-management system called Asthmatuner (Medituner AB, Sweden).The primary aim of this program is to evaluate if self-management with Asthmatuner improves asthma control more than traditional self-management. RCT with two arms, Asthmatuner …

pulmonary function test
  • 3 views
  • 26 Jan, 2021
  • 2 locations
Trikafta in Cystic Fibrosis Patients

immediate future. Each participant will be given Trikafta for approximately four weeks. The study researchers will monitor clinical endpoints that include forced expiratory volume (FEV1), sweat chloride

forced expiratory volume
pulmonary disease
bronchodilator
nasal potential difference
genetic disorder
  • 0 views
  • 17 Jun, 2021
  • 2 locations
Connexin Genotypes in Cystic Fibrosis

is performed for connexin 43 and 37 and MBL genotypes. Clinical disease is assessed longitudinally over 3 years by pulmonary function tests (FEV1 (forced expiratory volume in one second), FVC

lung transplant
fibrosis
cytokines
forced expiratory volume
pulmonary disease
  • 0 views
  • 27 Jan, 2021
  • 3 locations
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD

of adult patients with congenital alpha-1 antitrypsin (AAT) deficiency who have moderate airflow limitation (forced expiratory volume in 1 second 50% [FEV1] 80% of predicted) and FEV1/slow vital

blood test
alpha1-proteinase inhibitor (human)
emphysema
inhalations
chronic obstructive pulmonary disease
  • 11 views
  • 23 Jan, 2021
  • 1 location
A Study to Investigate the Effect of Vitamin D3 Supplementation on Asthma Symptoms in Adults With Asthma (VITDAS)

non-classical actions of vitamin D. However, vitamin D has been found to significantly improve airway function as measured by forced expiratory volume in one second (FEV1) in adults supplemented with

wheezing
vitamin d supplementation
chest tightness
forced expiratory volume
vitamins
  • 153 views
  • 07 May, 2021
  • 1 location
Lung Function Variability in Children and Adolescents

Long-term variability analysis of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) has been successfully used in research to predict the exacerbation of the disease in adult

lung function
peak expiratory flow
  • 0 views
  • 06 May, 2021
  • 1 location
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation

and Spirometry forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). The patient will follow the information contained in the information pack and the above

lung transplant
walk tests
walk test
forced vital capacity
forced expiratory volume
  • 76 views
  • 07 Nov, 2020
  • 1 location