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Found 58 clinical trials
Trikafta in Cystic Fibrosis Patients

expiratory volume (FEV1) and sweat chloride. Additionally, the researchers will obtain skin biopsy material and/or blood sample from each subject so that induced pluripotent stem (iPS) cells can be modified

nasal potential difference
cftr gene
spirometry
bronchodilator
forced expiratory volume
  • 8 views
  • 27 Apr, 2022
  • 3 locations
Connexin Genotypes in Cystic Fibrosis

is performed for connexin 43 and 37 and MBL genotypes. Clinical disease is assessed longitudinally over 3 years by pulmonary function tests (FEV1 (forced expiratory volume in one second), FVC

fibrosis
spirometry
lung transplant
forced expiratory volume
diabetes
  • 0 views
  • 25 Feb, 2022
  • 3 locations
Lung Transplant READY Pilot Study

to optimize the timing of referral for lung transplant. These guidelines recommend annual conversations with CF patients once their forced expiratory volume in one second (FEV1) is <50% predicted

forced expiratory volume
fibrosis
lung transplant
  • 0 views
  • 04 Oct, 2022
  • 1 location
A mHealth Intervention to Improve Symptom Control in Children and Adolescents With Difficult-to-control Asthma

, weight, height, Body Mass Index (BMI), forced expiratory volume in 1 second (FEV1), Asthma Control Questionnaire score, treatment received for asthma, number of exacerbations in the previous 6 months and

  • 0 views
  • 17 Sep, 2021
  • 4 locations
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

of adult patients with congenital alpha-1 antitrypsin (AAT) deficiency who have moderate airflow limitation (forced expiratory volume in 1 second 50% [FEV1] 80% of predicted) and FEV1/slow vital

washed out
chronic obstructive pulmonary disease
blood test
bronchodilator
deficiency
  • 32 views
  • 04 Oct, 2022
  • 1 location
Lung Function Variability in Children and Adolescents (LUV)

Long-term variability analysis of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) has been successfully used in research to predict the exacerbation of the disease in adult

lung function
peak expiratory flow
Accepts healthy volunteers
  • 0 views
  • 24 Feb, 2022
  • 1 location
Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD (RECUT)

recovery of forced expiratory volume in 1 second (FEV1), decrease duration of hospitalization, reduce treatment failure rate and improve clinical outcome. The additional therapeutic benefit on FEV1

antibiotics
acute exacerbation of chronic obstructive pulmonary disease
obstruction
forced expiratory volume
dyspnea
  • 17 views
  • 22 Jan, 2022
  • 1 location
Traxi Panniculus Retractor for Cesarean Delivery

This prospective, open-label, randomized-controlled trial is designed to evaluate the use of the Traxi panniculus retractor-- a commercially available Class I FDA-exempt device will improve surgical outcomes, cardiopulmonary function, and provider/patient satisfaction in morbidly obese women undergoing cesarean delivery.

  • 27 views
  • 15 Feb, 2022
An Open-Label, Multicenter Study to Evaluate the Long-term Safety of Weekly Intravenous Alpha1-Proteinase Inhibitor (Human), Modified Process 60 mg/kg in Subjects With Pulmonary Emphysema Due to Alpha1-Antitrypsin Deficiency (SPARTA-OLE)

This is a 2-year open-label, multicenter extension of the double-blind, placebo-controlled GTi1201 study. The purpose of this study is to obtain an additional 2 years of safety data for intravenously administered Alpha1-MP 60 mg/kg/week in subjects with alpha1-antitrypsin deficiency (AATD).

  • 0 views
  • 18 Oct, 2022
  • 3 locations
Feasibility of Home-based Exercise Program for Adults With Cystic Fibrosis

The main objective of this clinical pilot study is to evaluate the feasibility and impact of a home-based exercise program on clinical and patient-centered outcomes in adult with cystic fibrosis (CF) and inform the design of a larger clinical trial.

fibrosis
pulmonary rehabilitation
cystic fibrosis transmembrane conductance regulator
  • 0 views
  • 23 Mar, 2022
  • 1 location