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Found 47 clinical trials
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Management of Progressive Disease in Idiopathic Pulmonary Fibrosis

-modifying therapies, pirfenidone and nintedanib, have been approved worldwide. Both drugs reduce the disease progression as measured by progressive decline in forced vital capacity (FVC), with a reduction

  • 3 views
  • 31 Jul, 2021
  • 16 locations
None
Pectoralis and Serratus Muscle Blocks

The overall research plan is PECS/SAP blocks with liposomal bupivacaine improve the Overall Benefit Analgesia Score averaged over the postoperative days 1, 2, and 3. A 2-point reduction in OBAS will be considered the minimal clinically important benefit.

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study)

The investigators aim to assess the safety and efficacy of nebulized liposomal amphotericin B (ALN) as a complementary therapy to the usual systemic treatment in patients with invasive pulmonary aspergillosis and the utility of a non-routine test as a surrogate marker of efficacy. To this end, a 3-year phase I, …

  • 6 views
  • 13 Feb, 2021
  • 1 location
None
Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax

To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.

vats
pleurodesis
spontaneous pneumothorax
hemopneumothorax
minocycline
  • 0 views
  • 07 Nov, 2020
  • 1 location
None
Cardiovascular Effects of Exposure to Wood Smoke in Healthy Human Adults

Purpose: The study is designed to investigate cardiovascular effects of young healthy human subjects exposed to wood smoke. Participants: Approximately 80 young (18-35 years old) healthy subjects to complete. Procedure (methods): After consenting to participate in the study, subjects will undergo exposures over consecutive days, once to filtered air alone …

  • 11 views
  • 03 Jun, 2021
  • 1 location
None
Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax

The estimated recurrence rate of primary spontaneous pneumothorax is 23-50% after the first episode, and the optimal treatment remains unknown. In the recently published British Thoracic Society (BTS) guidelines, simple aspiration is recommended as first line treatment for all primary pneumothoraces requiring intervention. However, the 1 year recurrence rate of …

dyspnea
pleurodesis
tetracycline
cavity
thoracoscopy
  • 2 views
  • 07 Nov, 2020
None
Exhaled Breath Analysis Using eNose Technology as a Biomarker for Diagnosis and Disease Progression in Fibrotic ILD

The ILDnose study a multinational, multicenter, prospective, longitudinal study in outpatients with pulmonary fibrosis. The aim is to assess the accuracy of eNose technology as diagnostic tool for diagnosis and differentiation between the most prevalent fibrotic interstitial lung diseases. The value of eNose as biomarker for disease progression and response …

  • 0 views
  • 29 Jan, 2021
  • 4 locations
None
Digital Prevention of Asthma

Asthma self-management is dependent on support and education. To facilitate self-management have we developed and CE-mark a novel digital self-management system called Asthmatuner (Medituner AB, Sweden).The primary aim of this program is to evaluate if self-management with Asthmatuner improves asthma control more than traditional self-management. RCT with two arms, Asthmatuner …

pulmonary function test
  • 3 views
  • 26 Jan, 2021
  • 2 locations
None
Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease

face to face or via telephone and will be assessed to collect data for study objectives such as ALSFRS-R, Forced Vital Capacity, pain and spasticity score, and quality of life. Thirty (30) participants

motor neuron disease
primary lateral sclerosis
amyotrophic lateral sclerosis
cannabinoids
spasticity
  • 57 views
  • 07 Aug, 2021
  • 1 location
None
Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial

fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative decline in lung function [10% relative decline in forced vital capacity (FVC

nintedanib
acetylcysteine
forced vital capacity
pirfenidone
  • 0 views
  • 01 Oct, 2021
  • 7 locations