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Found 42 clinical trials
Management of Progressive Disease in Idiopathic Pulmonary Fibrosis (PROGRESSION)

-modifying therapies, pirfenidone and nintedanib, have been approved worldwide. Both drugs reduce the disease progression as measured by progressive decline in forced vital capacity (FVC), with a reduction

  • 23 views
  • 24 Mar, 2022
  • 9 locations
Pectoralis and Serratus Muscle Blocks for Analgesia After Minimally Invasive Cardiac Procedures

The overall research plan is PECS/SAP blocks with liposomal bupivacaine improve the Overall Benefit Analgesia Score averaged over the postoperative days 1, 2, and 3. A 20% reduction on geometric means (i.e., true ratio of geometric means of 0.80) in OBAS will be considered the minimal clinically important benefit.

  • 0 views
  • 18 Oct, 2022
  • 1 location
Exhaled Breath Analysis Using eNose Technology as a Biomarker for Diagnosis and Disease Progression in Fibrotic ILD

The ILDnose study a multinational, multicenter, prospective, longitudinal study in outpatients with pulmonary fibrosis. The aim is to assess the accuracy of eNose technology as diagnostic tool for diagnosis and differentiation between the most prevalent fibrotic interstitial lung diseases. The value of eNose as biomarker for disease progression and response …

  • 0 views
  • 04 Oct, 2022
  • 4 locations
Breathing Room Intervention to Achieve Better Lung Health in Older Adults

of this pilot is to examine the effect of Breathing Room on inspiratory muscle strength, spirometry confirmed ventilatory function (Forced Expiratory Volume in one second (FEV1), Forced Vital

Accepts healthy volunteers
  • 0 views
  • 29 Apr, 2022
  • 1 location
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial) (DEPTH)

on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also

COPD
cigarette smoke
doxycycline
  • 0 views
  • 07 Oct, 2022
  • 2 locations
Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease

face to face or via telephone and will be assessed to collect data for study objectives such as ALSFRS-R, Forced Vital Capacity, pain and spasticity score, and quality of life. Thirty (30) participants

motor neuron disease
spasticity
cannabinoids
amyotrophic lateral sclerosis
primary lateral sclerosis
  • 57 views
  • 05 Mar, 2022
  • 1 location
Study to Evaluate Efficacy and Safety in Chinese Patients With Late Onset Pompe Disease With Alglucosidase Alfa Treatmen (APOLLO-LOPD)

Primary Objective: To evaluate the effect of one-year Alglucosidase alfa treatment on motor function [Six-minute walk test (6MWT) and lung function predicted Forced vital capacity (FVC

alglucosidase alfa
beta-human chorionic gonadotropin
myozyme
gaa gene
deficiency
  • 0 views
  • 10 May, 2022
  • 1 location
Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial (PRECISIONS)

fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative decline in lung function [10% relative decline in forced vital capacity (FVC

pirfenidone
nintedanib
forced vital capacity
acetylcysteine
  • 5 views
  • 04 Oct, 2022
  • 21 locations
A Single Arm, Prospective, Open-label, Multi-center Study to Evaluate Efficacy and Safety in Chinese Patients With Late Onset Pompe Disease With Alglucosidase Alfa Treatment (APOLLO-LOPD)

Primary Objective: To evaluate the effect of one-year Alglucosidase alfa treatment on motor function [Six-minute walk test (6MWT) and lung function predicted Forced vital capacity (FVC

alglucosidase alfa
beta-human chorionic gonadotropin
myozyme
gaa gene
deficiency
  • 4 views
  • 28 Oct, 2022
  • 1 location
Connexin Genotypes in Cystic Fibrosis

(=(forced vital capacity), FEF75 % (Forced expiratory flow at 75% of the pulmonary volume) pred), BMI (percentiles), P. aeruginosa colonization, diabetes mellitus and survival to end-stage CF lung disease

lung transplant
prednisone
cytokines
diabetes
fibrosis
  • 0 views
  • 25 Feb, 2022
  • 3 locations