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Found 48 clinical trials
A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment

Supplementation with Iron and folate have been part of a worldwide strategy targeting anaemia and neural tube defects for many years. However, vitamin B12 deficiency has received much less

vitamin b12 supplementation
neural tube defects
  • 24 Mar, 2021
  • 2 locations
Perioperative Epidural Anesthesia and Analgesia on Gut Microbiota

B12 folate and vitamin K, and modulating gut integrity and permeability. Despite relatively stable microbiota during life, different illnesses, surgeries, medications dietary factors, and lifestyle

  • 26 Jan, 2021
  • 1 location
Modelle 001 TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate

A study that is blinded to the patient and the investigator where the combination of Arfolitixorin + 5-FU is compared to Calciumfolinate + 5-FU. The patients will be randomised and will receive the above described combination as IV bolus injections, peroperatively in conjuction with collection of the first tissue sample. …

liver metastasis
  • 25 Jan, 2021
  • 1 location
Phase I Study of MOv18 IgE a First in Class Chimeric IgE Antibody in Patients With Advanced Solid Tumours

This first in human study of the new therapeutic antibody MOv18 IgE in patients with advanced cancer seeks to demonstrate the potential for the use of this IgE antibody as an example of the use of the IgE class of antibodies for the treatment of cancer.

  • 27 Jan, 2021
  • 4 locations
Effect of Preoperative Intervention With Folic Acid and Vitamin B12 on Postoperative Neurobehavioral Changes in Children

Comparison of preoperative folic acid and VitB12 intervention on postoperative delirium and long-term neurobehavioral changes in children under general anesthesia

postoperative delirium
  • 24 Jan, 2021
  • 1 location
Mobile Health (m-Health) Coaching Program During Pregnancy

A parallel-group randomized controlled trial that will evaluate the efficacy of a mobile health (m-Health) program on influencing diet, supplement use and physical activity during pregnancy. Pregnant women will be randomly assigned to the intervention and the non-intervention arm. The intervention arm will receive free of cost m-Health application that …

  • 03 Aug, 2021
  • 1 location
Sulphur Amino Acid Requirements in Adults >60 Years

This study aims to determine the requirements for the sulphur amino acids in adults over the age of 60 years: the total sulphur amino acid requirement as methionine only. Methionine is an essential amino acid. the minimum methionine requirement as methionine in the presence of excess dietary cysteine. It is …

  • 28 Mar, 2021
  • 1 location
Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia

The purpose of this study is to determine the safety and dosing of drug Sotatercept, as a subcutaneous injection, to stimulate production of red blood cell production. To be given every 28 days for up to four doses.

  • 14 Mar, 2021
  • 1 location
Effectiveness of Comprehensive Tertiary Interventions on Incidence and Clinical Outcomes of Birth Defects

red blood cell folate level is below recommended level for preventing neural tube defects (400ng/ml) or with elevated homocysteine level (over th 80th percentiles, 6.8 mol/L) , and modifying their

red blood cell folate level
neural tube defect
  • 05 Aug, 2021
  • 1 location
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Platinum-Resistant Advanced High-Grade Epithelial Ovarian Primary Peritoneal or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression

next line of therapy. Folate receptor alpha (FR) positivity will be defined by the Ventana FOLR1 (FOLR1-2.1) CDx assay.

maintenance therapy
monoclonal antibodies
cancer of the ovary
cancer antigen 125
  • 10 Jul, 2021
  • 153 locations