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Found 262 clinical trials
Efficacy and Safety of Olaparib Olaparib + Bevacizumab Compared to Bevacizumab + 5-Fluorouracil (FU)

This is an efficacy and safety study of olaparib alone or in combination with bevacizumab being compared to bevacizumab with Fluorouracil (5-FU) in participants with unresectable or metastatic

systemic chemotherapy
adenocarcinoma
chemotherapy regimen
solid tumour
oxaliplatin
  • 10 views
  • 12 Sep, 2021
  • 125 locations
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

metastatic colorectal cancer that did not respond to fluorouracil.

metastatic colorectal cancer
tumor growth
irinotecan
panitumumab
monoclonal antibodies
  • 130 views
  • 07 Nov, 2020
  • 12 locations
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised Controlled Clinical Trial

Transient local skin reactions with topical Actinic Keratosis treatments such as 5-FluoroUracil (5-FU) often lead to non-adhesion from patients and thus to treatment failure. In regards to 5-FU

  • 0 views
  • 14 May, 2021
  • 24 locations
CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type Metastatic Colorectal Cancer

effectiveness of CMAB009 in combination with a standard and effective chemotherapy FOLFIRI5-Fluorouracil /Folinic acid plus Irinotecanfor RAS/BRAF wild-type, metastatic colorectal cancer in first-line setting

metastasis
folfiri regimen
measurable disease
leucovorin
adenocarcinoma
  • 3 views
  • 25 Jan, 2021
  • 2 locations
Combination Chemotherapy in Treating Patients With Esophageal Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is more effective in treating esophageal cancer. PURPOSE: Randomized phase …

surgery for esophageal cancer
conventional surgery
esophageal cancer
fluorouracil
epirubicin
  • 31 views
  • 07 Nov, 2020
  • 1 location
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)

The purpose of this study is to assess the efficacy and safety of pembrolizumab plus lenvatinib plus chemotherapy compared with pembrolizumab plus chemotherapy as first-line intervention in participants with metastatic esophageal carcinoma The primary hypotheses are that pembrolizumab plus lenvatinib plus chemotherapy is superior to pembrolizumab plus chemotherapy with respect …

  • 0 views
  • 15 Sep, 2021
  • 5 locations
The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer

The addition of Oxaliplatin to conventionally fractionated chemoradiation (FULV or capecitabine) is considered as standard in unresectable rectal cancer by the panel of experts. The Investigators addressed the question whether short-course preoperative radiotherapy with consolidating chemotherapy of FOLFOX4 may increase the rate of R0 resection in patients with unresectable rectal …

capecitabine
chemoradiotherapy
metastasis
oxaliplatin
  • 1 views
  • 07 Nov, 2020
  • 1 location
Bevacizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth …

metastatic colorectal cancer
capecitabine
monoclonal antibodies
leucovorin
adjuvant therapy
  • 7 views
  • 07 Nov, 2020
  • 1 location
Combination Chemotherapy and Trastuzumab in Treating Women With Stage I Stage II or Stage III HER2-Positive Breast Cancer

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. …

HER2
docetaxel
her2/neu-positive breast cancer
stage iii breast cancer
paclitaxel
  • 33 views
  • 07 Nov, 2020
  • 1 location
Intralesional 5-Fluorouracil (5FU) Topical Imiquimod Treatment for SCC

deliver drug to the tumor. For the proposed phase I clinical trial, the investigators will perform intralesional injections of a well characterized, potent chemotherapeutic agent 5-fluorouracil (5FU) with

fluorouracil
antineoplastic
imiquimod
  • 27 views
  • 15 Sep, 2021
  • 1 location