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Found 279 clinical trials
  • 0 views
  • 27 Jan, 2021
  • 5 locations
  • 0 views
  • 05 Apr, 2021
  • 2 locations
BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma

(JSMD194), cyclophosphamide, and fludarabine in treating participants with multiple myeloma that that has come back or remains despite treatment. Placing genes added in the laboratory into immune T-cells

progressive disease
immunomodulatory imide drug
induction therapy
monoclonal antibodies
plasmacytoma
  • 8 views
  • 27 Jan, 2021
  • 1 location
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

) without increasing the chance of not surviving the transplant. Up to 242 patients will be 'randomised' to the trial to receive either the established chemotherapy of fludarabine and melphalan or

hla-a
fludarabine
melphalan
alemtuzumab
transplant conditioning
  • 22 views
  • 24 Jan, 2021
  • 22 locations
Anti-CD19/CD22 Bispecific CAR-T Cell Therapy for MRD Positive ALL

regimen of fludarabine and cyclophosphamide followed by a single infusion of CD19/CD22 CAR+ T cells.

fludarabine
lymphoid leukemia
ejection fraction
cyclophosphamide
consolidation therapy
  • 9 views
  • 11 Apr, 2021
  • 1 location
  • 31 views
  • 24 Jan, 2021
  • 7 locations
Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies

This is a single arm, phase II trial of HLA-haploidentical related hematopoietic cells transplant (Haplo-HCT) using reduced intensity conditioning (fludarabine and melphalan and total body

mantle cell lymphoma
autologous transplant
prolymphocytic leukemia
transplant conditioning
t-cell lymphoma
  • 5 views
  • 11 Mar, 2021
  • 1 location
Human CD19 Targeted T Cells Injection(CD19 CAR-T) Therapy for Relapsed and Refractory CD19-positive Lymphoma.

. Patients will be given a conditioning chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of CD19 CAR+ T cells.

fludarabine
ejection fraction
follicular lymphoma
cancer chemotherapy
large b-cell lymphoma
  • 3 views
  • 23 Jan, 2021
  • 3 locations
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).

mantle cell lymphoma
prolymphocytic leukemia
hematologic disorder
cyclosporine
myeloproliferative syndromes
  • 146 views
  • 26 Jan, 2021
  • 1 location
MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

busulfan- and fludarabine-based conditioning regimens with busulfan therapeutic drug monitoring (TDM) for patients with various inherited metabolic disorders (IMD) and severe osteopetrosis (OP).

gm1 gangliosidosis
metabolic disorders
adrenoleukodystrophy
peroxisomal disorder
glycoprotein
  • 137 views
  • 25 Jan, 2021
  • 1 location