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Found 268 clinical trials
BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma

(JSMD194), cyclophosphamide, and fludarabine in treating participants with multiple myeloma that that has come back or remains despite treatment. Placing genes added in the laboratory into immune T-cells

cancer
immunoglobulin
measurable disease
fludarabine
monoclonal protein
  • 8 views
  • 27 Jan, 2021
  • 1 location
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

) without increasing the chance of not surviving the transplant. Up to 242 patients will be 'randomised' to the trial to receive either the established chemotherapy of fludarabine and melphalan or

myeloablative conditioning
melphalan
hla-a
fludarabine
blood cell count
  • 22 views
  • 24 Jan, 2021
  • 22 locations
Clofarabine Pre-allogeneic Stem Cell Transplant for Non-remission AML

The Investigators would like to study the incidence of complete remission (CR) at day +30 after Clofarabine followed by haploidentical transplant. The conditioning regimen used is Fludarabine

filgrastim
granulocyte colony stimulating factor
tacrolimus
clofarabine
colony stimulating factor
  • 0 views
  • 27 Jan, 2021
  • 1 location
Human CD19 Targeted T Cells Injection Therapy for Relapsed and Refractory CD19-positive Leukemia

given a conditioning chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of CD19 CAR+ T cells.

  • 0 views
  • 22 Jan, 2021
  • 1 location
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma

or metastatic clear cell renal cell carcinoma after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, and ALLO-647 to define a Phase 2 dose.

  • 0 views
  • 08 Apr, 2021
  • 2 locations
Human BCMA Targeted T Cells Injection Therapy for BCMA-positive Relapsed/Refractory Multiple Myeloma

chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of BCMA CAR+ T cells.

  • 0 views
  • 11 Mar, 2021
  • 3 locations
Tacrolimus and MMF as Post Grafting Immunosuppression After Conditioning With Flu TBI for HLA Matched Family Donor

sibling donor, with fludarabine and low-dose TBI, with pre- and post-transplant immunosuppression with tacrolimus and MMF. B. To evaluate the incidence of grade II-IV GVHD associated with

cancer
autologous transplant
lymphoma
hematologic malignancy
tacrolimus
  • 42 views
  • 07 Nov, 2020
  • 1 location
Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

-matched related donors. Preparation before transplant includes the chemotherapy drugs hydroxyurea, fludarabine, thiotepa, anti-thymocyte globulin, and cyclophosphamide. It also includes radiation.

blood transfusion
hemoglobin s
fludarabine
asthma
bone marrow transplant
  • 33 views
  • 13 Feb, 2021
  • 1 location
Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia

Fludarabine-based preparative regimen followed by an allogeneic hematopoietic stem cell transplant using related or unrelated donor in persons 0-70 years of age diagnosed with dyskeratosis

blood transfusion
glomerular filtration rate
g-csf
ejection fraction
fludarabine
  • 24 views
  • 25 Jan, 2021
  • 1 location
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).

b-cell lymphoma
myelodysplasia
burkitt's lymphoma
raeb
multiple myeloma
  • 146 views
  • 26 Jan, 2021
  • 1 location