Found 268 clinical trials
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)
Pharmacogenomics (PG) offers the opportunity to individualize treatment according to patient genetic variations which influence activity of enzyme metabolizing or acting in the pathway of prescribed chemotherapy drugs. This add-on research aims to prospectively investigate variations in several candidate genes related to all types of chemotherapeutic drugs and TBI used …
- 13 views
- 23 Jan, 2021
- 8 locations
Safety and Effectiveness of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML) a Cancer of the Blood
Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or is not …
- 39 views
- 15 Apr, 2021
- 39 locations
Haplo vs. URD in AML
This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …
- 4 views
- 23 Jan, 2021
- 14 locations
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.
- 142 views
- 25 Jan, 2021
- 20 locations
Fludarabine Based RIC for Bone Marrow Failure Syndromes
This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA
- 0 views
- 24 Jan, 2021
- 1 location
Orally Fludarabine Adriamycin and Dexamethasone (FAD) in Newly Diagnosed Peripheral T-cell Lymphomas (PTCL)
The primary objective of this study is to evaluate the efficacy of Fludarabine, Adriamycin and Dexamethasone (FAD) as first line therapy in patients with Peripheral T-cell lymphomas (PTCL
- 19 views
- 07 Nov, 2020
- 1 location
Umbilical Cord Blood Transplant Cyclophosphamide Fludarabine and Total-Body Irradiation in Treating Patients With Hematologic Disease
This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with
- 125 views
- 11 Apr, 2021
- 3 locations
Ibrutinib Fludarabine Phosphate Cyclophosphamide and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia
This phase II trial studies how well ibrutinib, fludarabine phosphate, cyclophosphamide, and obinutuzumab work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the
- 0 views
- 25 Jan, 2021
- 1 location
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation
transplants). The hypothesis is that thiotepa at a dose of 10mg/kg, in combination with melphalan (100mg/m2) and fludarabine (160mg/m2) as a reduced intensity conditioning regimen for alternative
- 12 views
- 16 May, 2021
- 1 location
Targeted Busulfan Fludarabine Etoposide Conditioning Regimen for HSCT in Childhood and Adolescent ALL.
To evaluate the outcome of hematopoietic stem cell transplantation using targeted busulfan, fludarabine, etoposide conditioning regimen in childhood and adolescent ALL.
- 8 views
- 07 Apr, 2021
- 1 location