Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 270 clinical trials
Safety and Effectiveness of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML) a Cancer of the Blood

Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or is not …

consolidation therapy
methotrexate
hematologic malignancy
remission
cytarabine
  • 39 views
  • 03 Feb, 2021
  • 37 locations
Haplo vs. URD in AML

This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …

busulfan
graft versus host disease
fludarabine
cell transplantation
mycophenolate mofetil
  • 4 views
  • 23 Jan, 2021
  • 14 locations
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

campath
hydroxyurea
methotrexate
hemoglobin s
graft-versus-host disease
  • 142 views
  • 25 Jan, 2021
  • 20 locations
Fludarabine Based RIC for Bone Marrow Failure Syndromes

This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA

  • 0 views
  • 24 Jan, 2021
  • 1 location
Venetoclax Added to Fludarabine + Busulfan Prior to Transplant for AML MDS and MDS/MPN

This clinical trial involves individuals who have been diagnosed with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), or MDS/myeloproliferative neoplasm-unclassifiable (MDS/MPN-unclassifiable) and are planning to have an allogeneic hematopoietic stem cell transplant ("bone marrow transplant"). The goal of this research study is to (1) test the …

myelomonocytic leukemia
flow cytometry
gilbert's syndrome
KRAS
remission
  • 31 views
  • 30 Jan, 2021
  • 1 location
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation

transplants). The hypothesis is that thiotepa at a dose of 10mg/kg, in combination with melphalan (100mg/m2) and fludarabine (160mg/m2) as a reduced intensity conditioning regimen for alternative

flow cytometry
myelodysplastic syndromes
hematologic malignancy
remission
intrathecal chemotherapy
  • 12 views
  • 28 Jan, 2021
  • 1 location
Donor Stem Cell Transplant With Treosulfan Fludarabine and Thiotepa in Treating Patients With Non-malignant Disorders

This phase II trial studies how well donor stem cell transplant, treosulfan, fludarabine, and thiotepa work in treating patients with non-cancerous disorders. Giving chemotherapy before a donor

bone marrow procedure
primary cancer
  • 0 views
  • 14 Feb, 2021
  • 2 locations
Ibrutinib Fludarabine Phosphate Cyclophosphamide and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

This phase II trial studies how well ibrutinib, fludarabine phosphate, cyclophosphamide, and obinutuzumab work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the

monoclonal antibodies
lymphoid leukemia
platelet count
gilbert's syndrome
cyclophosphamide
  • 0 views
  • 25 Jan, 2021
  • 1 location
Orally Fludarabine Adriamycin and Dexamethasone (FAD) in Newly Diagnosed Peripheral T-cell Lymphomas (PTCL)

The primary objective of this study is to evaluate the efficacy of Fludarabine, Adriamycin and Dexamethasone (FAD) as first line therapy in patients with Peripheral T-cell lymphomas (PTCL

absolute neutrophil count
dexamethasone
peripheral t-cell lymphoma
angioimmunoblastic t-cell lymphoma
large cell lymphoma
  • 19 views
  • 07 Nov, 2020
  • 1 location
Ibrutinib Fludarabine and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

-risk CLL has a poor clinical outcome when treated with conventional chemotherapy. This single-arm, phase II study investigates the combination of ibrutinib, fludarabine and pembrolizumab for treatment

night sweats
lymphocytosis
fatigue
lymphadenopathy
anemia
  • 11 views
  • 04 Feb, 2021
  • 1 location