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Found 268 clinical trials
CD19/CD22-Dual-STAR-T for Patients With B Cell Acute Leukemia(B-ALL)

This is a single center, single arm, open-lable phase I study to determine the safety and efficacy of CD19/CD22-Dual-STAR-T cells in patients with refractory and relapsed B cell acute leukemia .

  • 14 Jun, 2021
  • 1 location
Study of Efficacy and Safety of Valproic Acid in Chronic Lymphocytic Leukemia (CLL)

The purpose of this study is to determine whether Valproic acid, as a single agent is effective in the treatment of Chronic Lymphocytic Leukemia which has relapsed or is refractory to therapy with standard drugs.

lymphoid leukemia
nucleoside analog
neutrophil count
platelet count
  • 07 Nov, 2020
  • 1 location
Multi-center Trial of Revlimid and Rituximab for First-Line Treatment of Chronic Lymphocytic Leukemia (CLL)

The study is a two-arm, multi-center trial of Revlimid® and Rituximab, for the frontline treatment of patients with Chronic Lymphocytic Leukemia (CLL) designed and conducted by the CLL Research Consortium (CRC). The purpose of this study is to determine the response rate of the combination of Revlimid® and Rituximab in …

lymphoid leukemia
neutrophil count
  • 07 Nov, 2020
  • 3 locations
Reduce Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed Multiple Myeloma

This phase II trial studies how well a reduced intensity conditioning regimen after donor stem cell transplant works in treating patients with multiple myeloma that has come back (relapsed). Drugs used in chemotherapy, such as cyclophosphamide, tacrolimus, and mycophenolate mofetil, work in different ways to stop the growth of cancer …

tumor cells
monoclonal antibodies
monoclonal protein
mycophenolate mofetil
diffusion capacity of the lung for carbon monoxide
  • 29 Mar, 2021
  • 1 location
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

combined with induction chemotherapy. To compare two consolidation regimens: high dose cytarabine (HD Ara-C) and fludarabine & cytarabine (FLA) in standard risk patients. To compare

minimal residual disease
flow cytometry
  • 26 Jan, 2021
  • 59 locations
A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)

). Approximately 35 participants will be infused with Lenti-D Drug Product after myeloablative conditioning with busulfan and fludarabine. This trial will evaluate the efficacy and safety of autologous

  • 27 Jan, 2021
  • 9 locations
Study Evaluating Efficacy and Safety of CPI-613 in Combination With HD Cytarabine and Mitoxantrone Compared to HD Cytarabine and Mitoxantrone and Control Sub-groups: MEC and FLAG in Older Patients With R/R AML

and control sub-groups: combination of Mitoxantrone, Etoposide and Cytarabine (MEC) and combination of Fludarabine, Cytarabine, and Filgrastim (FLAG) in older patients with relapsed/refractory Acute

  • 25 Jan, 2021
  • 65 locations
A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

tolerated dose (MTD) for gilteritinib in sequential combination with fludarabine, cytarabine and granulocyte colony-stimulating factor (FLAG). The purpose of the phase 2 portion (dose expansion) is to

blast cells
refractory acute myeloid leukemia (aml)
serum bilirubin level
  • 16 Jun, 2021
  • 17 locations
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of …

myeloid leukemia
blast cells
consolidation therapy
  • 24 Jan, 2021
  • 1 location
A Trial to Evaluate the Safety and Efficacy of oNKord in Subjects With Acute Myeloid Leukemia

WiNK is a Phase I/IIa trial to evaluate the safety and efficacy of oNKord in 33 adults with acute myeloid leukemia (AML) who are in morphologic complete remission with residual measurable disease and with no strong indication for hematopoietic stem cell transplantation.

hematologic disorder
consolidation chemotherapies
transplant conditioning
cell transplantation
  • 24 May, 2021
  • 8 locations