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Found 268 clinical trials
CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies

. In the proposed trial, we will administer our CAR-T cell product to these participants as a single infusion. Participants will undergo (a) lymphodepletion with cyclophosphamide and fludarabine

cell transplantation
lymphoid leukemia
fludarabine
hematologic malignancy
large b-cell lymphoma
  • 12 views
  • 03 Mar, 2021
  • 2 locations
A Study to Evaluate the Safety of bb2121 in Subjects With High Risk Newly Diagnosed Multiple Myeloma (NDMM)

). Following manufacture of the drug product, subjects will receive fourth cycle of induction therapy followed by lymphodepleting therapy with fludarabine and cyclophosphamide prior to bb2121 infusion

chemotherapy regimen
fludarabine
induction therapy
cyclophosphamide
bone marrow procedure
  • 0 views
  • 24 May, 2021
  • 19 locations
CLAGE Sequential With Flu-Bu Conditioning for Refractory Acute Leukemia

study, we further modified the chemotherapy with cladribine replacing fludarabine aiming a more potent anti-leukemia effect. Meanwhile, we reduce the dose of busulfan for patients with poor performance

fludarabine
minimal residual disease
busulfan
cladribine
leukemia
  • 0 views
  • 30 Jan, 2021
  • 1 location
Modified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or Refractory B-Cell Lymphoma or Chronic Lymphocytic Leukemia

-Hodgkin?s B-cell lymphoma and chronic lymphocytic leukemia cells. Chemotherapy drugs such as fludarabine phosphate and cyclophosphamide can control cancer cells by killing them, by preventing their growth

neutrophil count
cell therapy
glomerular filtration rate
chronic lymphocytic leukemia
cancer
  • 0 views
  • 27 Jan, 2021
  • 1 location
IS-free Treg HaploHCT

>Radiation-Total Myeloid and Lymphoid Irradiation (TMLI Chemotherapy (Fludarabine, Thiotepa, Cyclophosphamide plus Mesna) Infusion of haplo Treg-enriched donor cells (experimental therapy

  • 0 views
  • 11 Feb, 2021
  • 1 location
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

. Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte globulin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping

  • 0 views
  • 02 Mar, 2021
  • 1 location
CAR T Cells After Lymphodepletion for the Treatment of IL13R 2 Positive Recurrent or Refractory Brain Tumors in Children

may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as as cyclophosphamide and fludarabine, work in different ways to stop the growth of tumor cells, either by

tumor cells
karnofsky performance status
neutrophil count
chemotherapy drug
cyclophosphamide
  • 0 views
  • 27 May, 2021
  • 1 location
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

has come back (recurrent) or does not respond to treatment (refractory). Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte globulin work in different

tumor cells
glomerular filtration rate
melphalan
cancer chemotherapy
etoposide
  • 0 views
  • 03 Mar, 2021
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and

white blood cell count
colony stimulating factor
melphalan
cancer
anemia
  • 37 views
  • 29 Jan, 2021
  • 1 location
EBV-TCR-T YT-E001 for Patients With EBV-positive Recurrent or Metastatic NPC

we will use for lymphodepletion is a combination of cyclophosphamide and fludarabine. Cyclophosphamide and fludarabine are the chemotherapy agents most commonly used for lymphodepletion in

chemotherapy regimen
epstein-barr virus dna
epstein-barr virus deoxyribonucleic acid
cyclophosphamide
solid tumour
  • 0 views
  • 24 Jan, 2021
  • 1 location