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Found 268 clinical trials
Hematopoietic Stem Cell Transplant for Sickle Cell Disease

cell transplants. Doctors will give patients a new drug (fludarabine) to see if this drug changes patients immune system and reduces the patient's cells (host) from rejecting donor cells (graft) after

acute chest syndrome
blood transfusion
sickle hemoglobin
fludarabine
stroke
  • 84 views
  • 28 Jan, 2021
  • 1 location
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation

The goal of this phase II clinical study is to learn about the safety of inotuzumab ozogamicin when given with fludarabine, with or without bendamustine, melphalan, and rituximab before and

b-cell acute lymphoblastic leukemia
stem cell transplantation
inotuzumab
methotrexate
human chorionic gonadotropin
  • 2 views
  • 16 May, 2021
  • 1 location
Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR

lymphodepletion with fludarabine and cyclophosphamide.

idelalisib
mantle cell lymphoma
measurable disease
b-cell lymphoma
left ventricular fractional shortening
  • 40 views
  • 27 Jan, 2021
  • 1 location
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

The study is a Phase II clinical trial. Patients will receive intensity modulated total body irradiation (TBI) at a dose of 3 Gy with standard fludarabine/ i.v. cyclophosphamide conditioning

alloimmunization
stroke
acute chest syndrome
anti-thymocyte globulin
sirolimus
  • 37 views
  • 26 Jan, 2021
  • 1 location
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease

with severe sickle cell disease (SCD) who undergo a non-myeloablative preparative regimen consisting of total body irradiation (TBI), cyclophosphamide and alemtuzumab (and fludarabine for haplo-SCT

acute chest syndrome
analgesia
cyclophosphamide
transplant conditioning
vaso-occlusive crisis
  • 14 views
  • 24 Apr, 2021
  • 1 location
Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haplo-HCT

hematologic malignancy. Conditioning will consists of fludarabine, cyclophosphamide, melphalan and total body irradiation (TBI) preparative regimen with a melphalan dose reduction for patients 55 years old

myeloablative conditioning
renal function
cyclophosphamide
ejection fraction
melphalan
  • 0 views
  • 05 Jun, 2021
  • 1 location
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

transplant team at WCI (Wilmot Cancer Institute)will be enrolled in the study. Patients will receive Fludarabine starting day -6 and Melphalan on day -2 and HBO (Hyperbaric Oxygen) therapy on day 0 of the

melphalan
cancer
fludarabine
leukemia
myeloid leukemia
  • 42 views
  • 26 Jan, 2021
  • 1 location
CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies

. In the proposed trial, we will administer our CAR-T cell product to these participants as a single infusion. Participants will undergo (a) lymphodepletion with cyclophosphamide and fludarabine

lymphoid leukemia
b-cell lymphoma
refractory acute lymphoblastic leukemia
large b-cell lymphoma
follicular lymphoma
  • 12 views
  • 03 Mar, 2021
  • 2 locations
A Study to Evaluate the Safety of bb2121 in Subjects With High Risk Newly Diagnosed Multiple Myeloma (NDMM)

). Following manufacture of the drug product, subjects will receive fourth cycle of induction therapy followed by lymphodepleting therapy with fludarabine and cyclophosphamide prior to bb2121 infusion

measurable disease
induction therapy
carfilzomib
cyclophosphamide
dexamethasone
  • 0 views
  • 24 May, 2021
  • 19 locations
CLAGE Sequential With Flu-Bu Conditioning for Refractory Acute Leukemia

study, we further modified the chemotherapy with cladribine replacing fludarabine aiming a more potent anti-leukemia effect. Meanwhile, we reduce the dose of busulfan for patients with poor performance

busulfan
cladribine
decitabine
minimal residual disease
fludarabine
  • 0 views
  • 30 Jan, 2021
  • 1 location