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Found 278 clinical trials
featured
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

>Objective: To test how safe and effective a combination of ibrutinib, short-course fludarabine, and pembrolizumab is for people with chronic lymphocytic leukemia (CLL), also known as

chronic lymphocytic leukemia
lymphadenopathy
neutrophil count
fatigue
night sweats
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Administration to treat CLL patients. T cells that interact with CLL cells can be removed by fludarabine, which is a drug given by vein and has been widely used to treat CLL. By adding a short course of

chronic lymphocytic leukemia
lymphadenopathy
fatigue
monoclonal antibodies
night sweats
  • 69 views
  • 15 Apr, 2019
  • 1 location
featured
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell renal cell carcinoma
carcinoma
primary cancer
clear cell carcinoma
renal cell cancer
  • 144 views
  • 22 Dec, 2020
  • 1 location
featured
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

anemia studies
aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the

anemia studies
aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
  • 86 views
  • 22 Dec, 2020
  • 1 location
A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatment

enough for rituximab, fludarabine & cyclophosphamide (R-FC).

chronic lymphocytic leukemia
chlorambucil
cyclophosphamide
rituximab
bendamustine
  • 436 views
  • 08 Nov, 2020
  • 1 location
Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years

experimental therapy with FLADx (fludarabine, cytarabine, DaunoXome).

  • 26 views
  • 21 Jan, 2021
  • 33 locations
Fludarabine and Cytarabine as Continuous Infusion Plus G-CSF Priming for Elderly Patients With Resistant AML

- To determine the feasibility of fludarabine and cytarabine as continuous infusion plus granulocyte-colony stimulating factor priming for elderly patients with resistant acute

colony stimulating factor
remission
granulocyte colony stimulating factor
acute promyelocytic leukemia
induction chemotherapy
  • 23 views
  • 07 Nov, 2020
  • 1 location
A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

expresses the E. coli enzyme purine nucleoside phosphorylase (PNP) under the control of a prostate-directed promoter. PNP converts systemically administered fludarabine (the prodrug) into 2

androgen suppression
gonadorelin
adenocarcinoma
biopsy of prostate
adenocarcinoma of prostate
  • 90 views
  • 07 Nov, 2020
  • 1 location
Targeted Busulfan Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in GRD

To evaluate the outcome of hematopoietic stem cell transplantation using targeted busulfan, fludarabine conditioning regimen in genetic rare disease

  • 0 views
  • 07 Apr, 2021
  • 1 location