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Found 256 clinical trials
Featured trial
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

>Objective: To test how safe and effective a combination of ibrutinib, short-course fludarabine, and pembrolizumab is for people with chronic lymphocytic leukemia (CLL), also known as

chronic lymphocytic leukemia
night sweats
neutrophil count
thrombocytopenia
fatigue
  • 359 views
  • 23 Nov, 2020
  • 1 location
Featured trial
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Administration to treat CLL patients. T cells that interact with CLL cells can be removed by fludarabine, which is a drug given by vein and has been widely used to treat CLL. By adding a short course of

chronic lymphocytic leukemia
night sweats
thrombocytopenia
fatigue
monoclonal antibodies
  • 169 views
  • 15 Apr, 2019
  • 1 location
Featured trial
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell renal cell carcinoma
carcinoma
metastatic cancer
clear cell carcinoma
renal cell cancer
  • 210 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 54 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 194 views
  • 22 Dec, 2020
  • 1 location
Flu-Bu-Mel Based Conditioning Regimen for Patients With Lymphoid Malignancies Undergoing Allo-HSCT

In this phase II clinical trial, we evaluate the efficacy and feasibility of conditioning regimen of fludarabine 150mg/m2, busulfan 9.6mg/kg, melphalan 100mg/m2 and etoposide 800mg/m2 in

  • 0 views
  • 04 Jun, 2021
  • 1 location
Study on TIL for the Treatment of Advanced Solid Tumors

resections or biopsies and infused i.v. into the patient after NMA lymphodepletion treatment with fludarabine and cyclophosphamide.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Reduced MBF Regimen for Patients >=55 Years With Myeloid Malignancies

In this multiple-center phase II study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan

  • 0 views
  • 28 Aug, 2023
  • 2 locations
Bisantrene Combination for Resistant AML

An Open-label, Phase II, Two-stage, Study of Xantrene (Bisantrene) in combination with Fludarabine and Clofarabine as Salvage Therapy for Adult Patients with Relapsed or Refractory Acute Myeloid

fludarabine
clofarabine
carbon monoxide
ejection fraction
  • 1 views
  • 30 Sep, 2021
  • 1 location
Study on TIL for the Treatment of r/r Gynecologic Tumors

expanded from tumor resections or biopsies and infused i.v. into the patient after NMA lymphodepletion treatment with fludarabine and cyclophosphamide.

  • 0 views
  • 26 Nov, 2021
  • 1 location