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Found 268 clinical trials
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Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

>Objective: To test how safe and effective a combination of ibrutinib, short-course fludarabine, and pembrolizumab is for people with chronic lymphocytic leukemia (CLL), also known as

ibrutinib
night sweats
anemia
lymphocytosis
lymphadenopathy
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Administration to treat CLL patients. T cells that interact with CLL cells can be removed by fludarabine, which is a drug given by vein and has been widely used to treat CLL. By adding a short course of

ibrutinib
monoclonal antibodies
night sweats
lymphadenopathy
anemia
  • 69 views
  • 15 Apr, 2019
  • 1 location
featured
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

primary cancer
carcinoma
clear cell carcinoma
metastatic cancer
renal cell cancer
  • 144 views
  • 22 Dec, 2020
  • 1 location
featured
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

anemia studies
anemia
myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the

anemia studies
anemia
myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
  • 86 views
  • 22 Dec, 2020
  • 1 location
A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatment

enough for rituximab, fludarabine & cyclophosphamide (R-FC).

cyclophosphamide
anemia
chronic lymphocytic leukemia
ofatumumab
rituximab
  • 436 views
  • 08 Nov, 2020
  • 1 location
Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years

experimental therapy with FLADx (fludarabine, cytarabine, DaunoXome).

  • 26 views
  • 21 Jan, 2021
  • 33 locations
Targeted Busulfan Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in GRD

To evaluate the outcome of hematopoietic stem cell transplantation using targeted busulfan, fludarabine conditioning regimen in genetic rare disease

  • 0 views
  • 07 Apr, 2021
  • 1 location
A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

expresses the E. coli enzyme purine nucleoside phosphorylase (PNP) under the control of a prostate-directed promoter. PNP converts systemically administered fludarabine (the prodrug) into 2

transrectal ultrasound
gonadorelin
biopsy of prostate
orchiectomy
bilateral orchidectomy
  • 90 views
  • 07 Nov, 2020
  • 1 location
Busulfan and Fludarabine as Conditioning for Allogeneic Stem Cell Transplantation: a Pharmacokinetic Study

A study of pharmacokinetics of daily intravenous busulfan

busulfan
fludarabine
cell transplantation
  • 38 views
  • 07 Nov, 2020
  • 1 location