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Found 266 clinical trials
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Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

>Objective: To test how safe and effective a combination of ibrutinib, short-course fludarabine, and pembrolizumab is for people with chronic lymphocytic leukemia (CLL), also known as

anemia
cancer
lymphocytosis
lymphoma
lymphadenopathy
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Administration to treat CLL patients. T cells that interact with CLL cells can be removed by fludarabine, which is a drug given by vein and has been widely used to treat CLL. By adding a short course of

anemia
lymphocytosis
lymphoma
lymphadenopathy
monoclonal antibodies
  • 69 views
  • 15 Apr, 2019
  • 1 location
featured
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell renal cell carcinoma
renal cell cancer
clear cell carcinoma
carcinoma
primary cancer
  • 144 views
  • 22 Dec, 2020
  • 1 location
featured
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

anemia
anemia studies
myelodysplastic syndrome (mds)
myelodysplastic syndromes
aplastic anemia
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the

anemia
anemia studies
myelodysplastic syndrome (mds)
myelodysplastic syndromes
aplastic anemia
  • 86 views
  • 22 Dec, 2020
  • 1 location
A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatment

enough for rituximab, fludarabine & cyclophosphamide (R-FC).

anemia
lymphocytosis
ofatumumab
rituximab
cyclophosphamide
  • 436 views
  • 08 Nov, 2020
  • 1 location
Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years

experimental therapy with FLADx (fludarabine, cytarabine, DaunoXome).

  • 26 views
  • 21 Jan, 2021
  • 25 locations
Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)

subjects will be infused with Lenti-D Drug Product after myeloablative conditioning with busulfan and fludarabine. This trial will evaluate the efficacy and safety of autologous CD34+ hematopoietic

  • 0 views
  • 04 Nov, 2020
  • 9 locations
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Pharmacogenomics (PG) offers the opportunity to individualize treatment according to patient genetic variations which influence activity of enzyme metabolizing or acting in the pathway of prescribed chemotherapy drugs. This add-on research aims to prospectively investigate variations in several candidate genes related to all types of chemotherapeutic drugs and TBI used …

cancer
lymphoid leukemia
remission
cell transplantation
chemotherapy drug
  • 13 views
  • 21 Apr, 2019
  • 4 locations
Fludarabine Based RIC for Bone Marrow Failure Syndromes

This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA

  • 0 views
  • 15 Jul, 2020
  • 1 location