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Found 15 clinical trials
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Anti-viral Therapy in Alzheimer's Disease

Anti-viral therapy in Alzheimer's disease will investigate the efficacy of treating patients with mild Alzheimer's disease with the U.S.A marketed generic anti-viral drug Valtrex (valacyclovir, 500mg oral tablet). Valacyclovir, titrated to 4 grams per day, repurposed to treat Alzheimer's disease, will be compared to matching placebo in the treatment of …

cognitive impairment
memantine
cholinesterase
mini-mental state examination
cholinesterase inhibitors
  • 84 views
  • 03 Feb, 2021
  • 3 locations
None
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study

The investigators will conduct tau positron emission tomography (PET) scans on 125 adults using the radiopharmaceutical Flortaucipir F18 ([18F]AV-1451). This will allow the investigators to determine tau deposition across adults of different ages and assess the relationship of current tau burden to cognitive function and amyloid deposition collected over the …

cognitive decline
amyloid
amyloidosis
flortaucipir
positron emission tomography
  • 73 views
  • 03 Feb, 2021
  • 1 location
None
Dominantly Inherited Alzheimer Network (DIAN)

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

cognitive impairment
alzheimer's disease
  • 165 views
  • 28 Jun, 2021
  • 28 locations
None
The Diagnostic Value of Hybrid PET/MR for Systemic Amyloidosis

PET imaging agents (11C-PIB or 18F-florbetapir) have been shown to be effective as novel positron tracers to detect potential amyloid deposition in some small sample studies. The investigators will

  • 0 views
  • 03 Nov, 2021
  • 1 location
None
Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients With Significant White Matter Disease

undergo 3T structural MRI (including T1, PD/T2, FLAIR, GRE, DTI, ASL, and resting state fMRI), glucose PET, amyloid PET (using AV-45 florbetapir) and neuropsychological testing, as well as blood sampling

cognitive impairment
cognitive decline
mini-mental state examination
neuropsychological test
amyloid
  • 10 views
  • 24 Jan, 2021
  • 8 locations