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Found 12 clinical trials
Featured trial
A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB037 in Subjects With Prodromal or Mild Alzheimer's Disease

A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB037 in Subjects With Prodromal or Mild Alzheimer's Disease

  • 87 views
  • 25 Mar, 2021
  • 1 location
Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy

This is a pilot study designed to assess for relative change in cardiac 18F Florbetapir uptake in patients with AL cardiac amyloidosis after appropriate chemotherapy.

florbetapir
amyloidosis
cardiac mri
nt-probnp
  • 0 views
  • 26 Feb, 2022
  • 1 location
SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid

six-week sleep intervention program. A sub-group of fifty participants will undergo Florbetapir-Positron-emission tomography (PET) imaging during the one-year reassessment to examine the efficacy of

dementia
cognitive behavioral therapy for insomnia
cognitive therapy
behavior therapy
initial insomnia
  • 42 views
  • 14 Feb, 2022
  • 1 location
Cerebral Amyloid Imaging Using Florbetapir (AV-45) (IDEA3)

This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia

cognitive assessment
florbetapir
amyloidosis
18f-av-45
amyloid
  • 3 views
  • 24 Jan, 2022
  • 1 location
Entire-body PET Scans for Multiple Sclerosis (EPSMS)

To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.

nervous
disease or disorder
demyelination
Accepts healthy volunteers
  • 0 views
  • 22 Apr, 2022
  • 1 location
Molecular Imaging of Primary Amyloid Cardiomyopathy (MICA)

Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will develop a novel approach to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac …

remission
multiple myeloma
cardiac amyloidosis
natriuretic peptide
heart failure
  • 28 views
  • 23 Feb, 2022
  • 1 location
MRI and PET Biomarkers for Cognitive Decline in Older Adults

The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to this study includes …

mental state examination
tau protein
florbetapir
positron emission tomography
cognitive decline
  • 7 views
  • 24 Jan, 2022
  • 1 location
Valacyclovir for Mild Cognitive Impairment (VALMCI)

Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI) patients (eMCI and lMCI). The trial will directly address the long-standing viral etiology hypothesis of Alzheimer's disease (AD) which posits …

  • 209 views
  • 11 May, 2022
  • 1 location
Dominantly Inherited Alzheimer Network (DIAN) (DIAN)

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

alzheimer's disease
cognitive impairment
Accepts healthy volunteers
  • 201 views
  • 25 Mar, 2022
  • 18 locations
The Diagnostic Value of Hybrid PET/MR for Systemic Amyloidosis

PET imaging agents (11C-PIB or 18F-florbetapir) have been shown to be effective as novel positron tracers to detect potential amyloid deposition in some small sample studies. The investigators will

  • 0 views
  • 13 May, 2022
  • 1 location