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Found 1139 clinical trials
Fibrosis and the Fontan

the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the

  • 04 Jun, 2021
  • 1 location
Myocardial Fibrosis, Function and Aging (MARVEL)

In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship

Accepts healthy volunteers
  • 13 Mar, 2022
  • 1 location
Study of Sirolimus in Idiopathic Retroperitoneal Fibrosis

Retroperitoneal fibrosis refers to a group of diseases characterized by hyperplasia of the fibrosclerotic tissues in the retroperitoneal space, which can compress the surrounding ureters and

  • 15 Feb, 2022
  • 1 location
Prednisone in Cystic Fibrosis Pulmonary Exacerbations (PIPE)

This will be a 5 year randomized, double blind, placebo controlled trial of 7 days of oral prednisone in cystic fibrosis (CF) patients receiving intravenous (IV) antibiotic treatment for a

  • 03 Mar, 2022
  • 12 locations
PFOX: Pulmonary Fibrosis Ambulatory Oxygen Trial (PFOX)

The fibrotic interstitial lung diseases (fILD) are characterised by lung scarring, distressing breathlessness and poor health-related quality of life. Exertional desaturation (low blood oxygen during exercise) is a hallmark of fILD, occurring in over 50% of patients. It is sometimes treated with ambulatory oxygen therapy (AOT), which involves breathing supplemental …

  • 12 Feb, 2022
  • 1 location
Telerehabilitation in Patients With Idiopathic Pulmonary Fibrosis

It is to determine the effectiveness of different telerehabilitation exercise programs received to 2 groups randomly formed in idiopathic pulmonary fibrosis (IPF) patients. The cases meeting the

  • 23 Mar, 2022
  • 1 location
A Prospective Study of Cyclophosphamide Treatment for Idiopathic Retroperitoneal Fibrosis

This prospective, interventional, controlled study is aimed to evaluate the efficacy and safety of cyclophosphamide in the treatment of idiopathic retroperitoneal fibrosis, which refers to the

  • 26 Mar, 2021
  • 1 location
Trial to Compare Radiation Fibrosis With Five Versus Three Fractions

Post meno-pausal women with T1 Breast cancers will be randomized to receive either 600 centiGray (cGy) X 5 over five consecutive days (arm 1) versus 800 cGy X 3 fractions given every other day (arm 2). Patients will complete treatment in one week. All patients will be followed a month …

  • 25 Jul, 2021
  • 4 locations
Management of Progressive Disease in Idiopathic Pulmonary Fibrosis (PROGRESSION)

Idiopathic pulmonary fibrosis (IPF) is a prototype of chronic, progressive, and fibrotic lung disease. It has been considered rare, with an incidence estimated to 11.5 cases per 100 000

  • 24 Mar, 2022
  • 5 locations
4D-710 in Adult Patients With Cystic Fibrosis (CF)

This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with CF who are ineligible for or unable to tolerate CFTR modulator therapy.

cftr gene
cystic fibrosis transmembrane conductance regulator
forced expiratory volume
  • 17 Jun, 2022
  • 2 locations