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Found 1138 clinical trials
  • 70 views
  • 13 May, 2022
  • 106 locations
Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

cholangitis and suspected liver fibrosis

endoscopic retrograde cholangiopancreatography
fibrosis
ursodiol
MRI
magnetic resonance cholangiopancreatography
  • 32 views
  • 09 Jun, 2022
  • 52 locations
Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate

fibrosis
pulmonary function test
grip
combinations
mucolytics
  • 6 views
  • 22 Apr, 2022
  • 14 locations
Study of Efficacy and Safety of NIS793 in Combination With Standard of Care (SOC) Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) - daNIS-2

pancreatic ductal adenocarcinoma (mPDAC). This study aims to explore whether blockade of Transforming Growth Factor β (TGFβ) in combination with gemcitabine/nab-paclitaxel can reduce fibrosis in PDAC

  • 0 views
  • 14 May, 2022
  • 15 locations
A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B (Piranga)

function and without significant fibrosis/cirrhosis. The platform design allows comparison of multiple NME combination therapies against a common control, and introduction of additional treatment arms at

fibrosis
entecavir
combination therapy
tenofovir
hepatitis b antigen
  • 1 views
  • 27 Jun, 2022
  • 26 locations
The Clinical Cure Project of Chronic Hepatitis B in China

who achieve clinical cure will further reduce liver inflammation, fibrosis and risks of liver cirrhosis and cancer in the future. This study was initiated in May 2018 and plans to recruit 30,000

fibrosis
hepatitis b antigen
hepatitis b e antigen
cancer
cirrhosis
  • 12 views
  • 14 Feb, 2022
  • 1 location
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

  • 193 views
  • 26 Jan, 2021
  • 98 locations
HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID)

HEAL-COVID is jointly Sponsored by Cambridge University Hospitals NHS Foundation Trust and The University of Cambridge. The acute effects of COVID-19 are now well described. Evidence is emerging of serious longer-term complications occurring in the convalescent phase of the illness in a significant proportion of patients particularly cardiovascular and pulmonary …

  • 0 views
  • 02 Aug, 2021
  • 1 location
VAPORHCS/OHSU J: MRI and Devices

This is a database study of clinically indicated MRIs on patients with permanent pacemakers and implantable cardioverter defibrillators.

  • 0 views
  • 02 Feb, 2022
  • 2 locations
Fibrosis and the Fontan

the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the

  • 0 views
  • 04 Jun, 2021
  • 1 location