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Found 1101 clinical trials
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

lung carcinoma
cancer
advanced lung cancer
cancer chemotherapy
  • 0 views
  • 22 Mar, 2022
  • 3 locations
PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort (PROSAIC-19)

DESIGN Longitudinal prospective observational multicentre study. Primary objective: Understand the immune mechanisms driving COVID-19 disease in patients with a history of lung disease

pulmonary disease
COPD
asthma
blood test
Accepts healthy volunteers
  • 35 views
  • 09 Jun, 2022
  • 1 location
Romanian Kidney Transplant Cardiovascular Risk Registry

Kidney transplantation (KT) represents the best treatment for patients with end-stage kidney disease, being associated with improved outcomes and reduced mortality. Although the survival benefit with KT is mostly attributable to reduction in cardiovascular (CV) disease, KT recipients continue to remain at higher risk for CV-related morbidity and mortality when …

hypertension
chronic renal failure
kidney transplant
heart failure
kidney disease
  • 0 views
  • 24 Jan, 2021
  • 1 location
The Clinical Course of Interstitial Pneumonia With Autoimmune Features

Interstitial pneumonia with autoimmune features (IPAF) is a chronic interstitial lung disease (ILD) with some laboratoristic and/or clinical features of autoimmune disease, but without meeting criteria of connective tissue disease (CTD), and with no other causes of ILD. Despite recent efforts to standardize the diagnosis of IPAF, subjects with IPAF …

lung transplant
  • 8 views
  • 20 Apr, 2022
  • 1 location
Transformative Research in Diabetic Nephropathy (TRIDENT)

This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that …

diabetic nephropathy
nephropathy
diabetes
kidney biopsy
  • 410 views
  • 27 Jan, 2022
  • 17 locations
Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy

Recently chimeric antigen receptor (CAR) T-cell therapy, a new class of chemo therapy, has gained regulatory approval for the treatment of diseases such as B-cell lymphoma. Known side effects include cytokine release syndrome, which has been described to lead to myocarditis, but larger studies exploring this relationship are currently lacking. …

b-cell lymphoma
cardiac mri
lymphoma
chemotherapy regimen
MRI
  • 0 views
  • 06 Jul, 2022
  • 1 location
Exoskeleton Footwear to Improve Walking

The purpose of this study is to determine the best assistance level of an exoskeleton footwear (EF) that can assist walking for people older than 40 with and without peripheral artery disease (PAD). The test will be performed on two different groups of people for this study that include: 1) …

intermittent claudication
angiography
diabetes
arteriopathy
peripheral arterial diseases
  • 22 views
  • 23 Mar, 2022
  • 1 location
Precision Medicine in LN: A Multicenter Proof-of-concept Study for Histopathological Biomarkers Analysis in Renal Biopsy

Lupus nephritis (LN) may affect approximately half of patients with Systemic Lupus Erythematosus (SLE). LN is a major cause of morbidity and the most important predictor of mortality in patients with SLE. Some 5-20% of patients with LN may develop end-stage renal disease within 10 years of follow-up from the …

cyclophosphamide
tacrolimus
belimumab
lupus
treatment regimen
  • 0 views
  • 11 May, 2022
  • 1 location
Gastro-intestinal Physiology After Anti-Reflux Procedures (GASP)

Gastro-oesophageal reflux disease (GORD) affects 1 in 4 adults and is a condition where stomach acid leaks back up into the oesophagus (gullet). It can cause an uncomfortable burning feeling in the chest and even lead to problems such as cancer of the oesophagus. Thankfully most people feel better by …

  • 0 views
  • 07 Jun, 2022
  • 1 location
Profiling Recovery of Those Discharged Into the Community With COVID-19

Currently, there are few studies that have been established that consist of a variety of established and coherent approaches that sought to profile the determinants of recovery, nor used interrogative procedures to understand lasting physical impairment. In this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress …

acute respiratory infections
  • 0 views
  • 02 Jun, 2022
  • 1 location