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Found 1087 clinical trials
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium (POWER)

To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.

heart surgery
  • 0 views
  • 02 Jun, 2022
  • 1 location
Impact of SARS-CoV-2/COVID-19 Related Pneumonia on Lung Function and Structure.

Prospective study in a group of patients with COVID-19 pneumonia.

  • 0 views
  • 25 Jun, 2021
  • 1 location
Inflammatory Profiling in Chronic Lung Disease

The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis (PREDICT-HP)

Up to 135 patients with hypersensitivity pneumonitis will be enrolled at 5 clinical centers across the United States. Patients will be followed for 24 months to determine if biomarkers in the blood can predict disease progression.

  • 1 views
  • 19 Apr, 2022
  • 5 locations
Sleep Hygiene, Sarcopenia, and Cognitive Function in Respiratory Disease

We aim to clarify the relationship between sleep hygiene and the onset of sarcopenia or cognitive dysfunction using sleep time, arousal, and sleep quality as indicators in COPD or IPF patients, and clarify the effects of sleep hygiene on disease progression and life prognosis.

  • 0 views
  • 24 Mar, 2022
  • 1 location
DKK3 for Prognosis and Monitoring of GFR Loss in Heart Failure

The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) loss are needed. Recently, urinary dickkopf-3 (DKK3) has been proposed to predict eGFR loss in patients with CKD, independent of presence of albuminuria. The investigators sought …

heart failure
nephropathy
glomerular filtration rate
diabetes
hypertension
  • 1 views
  • 05 Jun, 2022
  • 1 location
Effect of Chronic Inflammation on Myocardial Perfusion and Function

Background Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF. Researchers want to use psoriasis as a disease model of chronic inflammation to further study the link between inflammation and myocardial dysfunction. Objective To learn if chronic inflammation affects the …

heart failure
Accepts healthy volunteers
MRI
pet/ct scan
  • 0 views
  • 04 Oct, 2022
  • 1 location
Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease (AFiRM)

Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: To establish a multiparametric renal MRI protocol in CKD cohorts. To use multiparametric MRI to characterise people …

  • 0 views
  • 25 Mar, 2022
  • 1 location
Cardiac MRI and Cardiac Allograft Rejection

In this a prospective, blinded, collaboration study between pediatric and adult transplant departments. Cardiac MRI data on patient with heart transplantations will be collected during years 2020-2022. Based on sample size calculations, the data has enough power to answer the question, whether MRI can be used as a noninvasive diagnostic …

  • 2 views
  • 02 Mar, 2022
  • 1 location
Non-invasive Evaluation of Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease by Assessment of Spleen Stiffness Using Vibration Controlled Transient Elastography

Hypothesis: The severity of portal hypertension in compensated advanced chronic liver disease (cACLD) can be assessed using vibration controlled transient elastography (VCTE) via the FibroScan 502 Touch by measuring SS (splenic stiffness) Specific Aims: SS by VCTE will be measured in this single center clinical study comprising of 200 patients …

  • 0 views
  • 01 Feb, 2021
  • 1 location