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Found 46 clinical trials
Investigation on Novel Route of Gut Microbiota Products for Bariatric Surgery to Improve Non-alcoholic Steatohepatitis and Development on Therapeutic Implications

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Non-alcoholic steatohepatitis (NASH) is an aggressive form of NAFLD with remarkable inflammatory features which may cause advanced fibrosis and liver cancer. So far there is no FDA-approved drug for treating NASH. A 10% weight loss by life style …

steatosis
liver cancer
fibrosis
chronic disease
Accepts healthy volunteers
  • 0 views
  • 15 Oct, 2022
  • 1 location
Disease Loads and Status of Treatment

The aim of study is to evaluate the current prevalence of HDV infection, and comprehensively analyze the interaction between HDV and HBV infections in the era of NAs in Taiwan. Investigators plan to set up a platform for HDV positive patients in Taiwan to invite sites or hepatologists who are …

hepatitis b core antibody
  • 0 views
  • 13 Mar, 2022
  • 1 location
Alpha-1 Antitrypsin Deficiency Adult Liver Study

The investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed. In addition, the investigators believe that the genetic and environmental factors that play an important role in the development of alpha-1 antitrypsin (AAT) liver disease, can …

deficiency
cirrhosis
liver injury
liver disease
alpha1-proteinase inhibitor (human)
  • 262 views
  • 21 Mar, 2022
  • 3 locations
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

cancer chemotherapy
advanced lung cancer
cancer
lung carcinoma
  • 0 views
  • 22 Mar, 2022
  • 3 locations
Volatile Organic Compounds for the Assessment of Liver Disease (VOCAL)

This study aims to determine whether a breath test could be used for early detection of hepatic fibrosis, cirrhosis or hepatocellular carcinoma. Patients who are attending for a planned liver outpatient services or investigations will be approached to provide a breath sample. Multi platform mass spectrometry analysis will be performed …

Accepts healthy volunteers
hepatic fibrosis
carcinoma
cancer
liver disease
  • 0 views
  • 25 May, 2022
  • 1 location
Microvesicles and Monocytes to Predict Mortality of Patients With Cirrhosis (PROMICE)

Chronic liver diseases related to viral hepatitis, metabolic syndrome or excessive alcohol consumption can evolve towards cirrhosis. Cirrhosis is responsible for 170 000 deaths per year in Europe. Initially asymptomatic and called "compensated" it can become "decompensated" with the developement of acute complications such as infections, ascites or variceal bleeding. …

interferon
hepatic failure
cirrhosis
hepatitis
stiffness
  • 23 views
  • 03 May, 2022
  • 4 locations