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Found 103 clinical trials
Effect of Home Rehabilitation on State of Patients With PAH HFREF and IHD

The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and body mass composition in patients with pulmonary arterial hypertension (PAH) or left ventricular heart failure …

pulmonary arterial pressure
heart failure
pulmonary arterial hypertension
rehabilitation therapy
connective tissue diseases
  • 8 views
  • 21 Feb, 2021
  • 2 locations
Training Single Arm

The pulmonary hypertension is a disease, which tends to a progredient right heart failure. Although there was a large progress in development of medical therapy, the quality of life, the physical efficiency and the prognosis of the patients are still limited. The aim of the study is to examine the …

heart failure
right ventricular failure
right heart catheterization
  • 1 views
  • 10 May, 2021
  • 1 location
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE

To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive pulmonary embolism (PE)

alteplase
troponin t
ct scan
pulmonary embolism
troponin
  • 71 views
  • 14 Mar, 2021
  • 2 locations
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere …

fibrosarcoma
leiomyosarcoma
platelet count
liposarcoma
undifferentiated pleomorphic sarcoma
  • 0 views
  • 28 Jun, 2021
  • 1 location
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

  • 0 views
  • 16 Mar, 2021
  • 1 location
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the …

lung disease
hypertension
assisted ventilation
emphysema
fibrosis
  • 288 views
  • 07 May, 2021
  • 1 location
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

systemic sclerosis
cyclophosphamide
intravenous immunoglobulin
MRSS
prednisone
  • 176 views
  • 27 Jan, 2021
  • 2 locations
Development of Novel Physiological CMR Methods in Health and Disease

Physiological cardiovascular stress test plays a crucial role in the assessment of patients with suspected heart disease. There are several methods of cardiac physiological stress tests and each of them offer varied insight into cardiac physiological adaptation: passive leg raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress test. …

exercise stress test
heart disease
  • 34 views
  • 15 Jul, 2021
  • 1 location
Protein Phosphatase 2A Inhibitor in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

gliosarcoma
oligodendroglioma
platelet count
renal function
recurrent disease
  • 22 views
  • 12 Sep, 2021
  • 1 location
Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulmonary hypertension caused by heart failure.

heart failure
hypertension
rehabilitation program
  • 0 views
  • 06 Jun, 2021
  • 1 location