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Found 103 clinical trials
Selexipag for the Treatment of Schistosomiasis-Associated Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a severe, progressive and potentially fatal disease that impairs the pulmonary circulation and leads to right ventricular failure. One of the world most prevalent etiologies of PAH is schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH). New drugs have emerged to treat other forms of PAH, but their …

endothelin
endothelin receptor antagonist
pulmonary arterial hypertension
right ventricular failure
phosphodiesterase-5 (pde-5) inhibitor
  • 0 views
  • 26 Jan, 2021
  • 1 location
THERAPY-HYBRID-BPA Trial

Riociguat could improve the exercise capacity and residual symptoms in patients with chronic thromboembolic pulmonary hypertension (CTEPH) even after normalization of pulmonary arterial pressure by balloon pulmonary angioplasty (BPA). This randomized controlled trial study aimed to clarify whether the improvement of peak cardiac index (CI) during exercise maintains or not …

riociguat
right heart catheterization
  • 2 views
  • 26 Jan, 2021
  • 1 location
Levosimendan Administration in Pulmonary Hypertension

The aim of the study is to examine the pharmacokinetics and pharmacodynamic properties of Levosimendan in cardiac surgery patients with pulmonary hypertension and impaired right ventricular function.

anesthesia
left ventricular dysfunction
levosimendan
hypertension
  • 0 views
  • 30 Jan, 2021
  • 1 location
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown of oral nitrate.

ejection fraction
heart failure
heart disease
hypertension
right heart catheterization
  • 21 views
  • 17 Sep, 2021
  • 2 locations
Ketones for Pulmonary Hypertension - Effects on Hemodynamics

In the present study, patients with idiopathic pulmonary hypertension (IPAH) and chronic thromboembolic pulmonary hypertenion will be investigated in a randomized cross-over design with ketone infusions and placebo. Invasive and non-invasive hemodynamics will be evaluated

  • 0 views
  • 27 Jan, 2021
  • 1 location
Treatment of Pulmonary Hypertension in High-risk Cardiac Surgery Patients Using Inhalational and Intravenous Agents

The aim of this study is to examine and compare the effect of Levosimendan and Milrinone administered intravenously and via inhalation respectively in cardiac surgery patients with pulmonary hypertension and right ventricular dysfunction.

  • 0 views
  • 04 Feb, 2021
  • 1 location
Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension

To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension on blood markers (serum markers of iron and red blood cell homeostasis and micro-RNAs known to be associated with PH).

  • 0 views
  • 30 Apr, 2021
  • 1 location
A Study for the Identification of Biomarker Signatures for Diagnosis of Pulmonary Hypertension (PH) in Participants at Low or Intermediate Probability of PH Undergoing Cardiac Magnetic Resonance Imaging

The primary purpose of this study is to estimate the percentage of participants in the population considered clinically as not having pulmonary hypertension (PH) that are positive for PH biomarker (micro ribonucleic acid [RNA]); estimate the percentage of participants in the population considered clinically as not having PH that are …

right heart catheterization
  • 0 views
  • 10 Sep, 2021
  • 10 locations
Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil

To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without Sildenafil

  • 0 views
  • 28 Apr, 2021
  • 1 location
Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension

To study hemodynamic effects of acute normobaric hypoxia during exercise in patients with pulmonary hypertension in a single-center randomized controlled trial.

  • 0 views
  • 01 May, 2021
  • 1 location