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Found 240 clinical trials
Metastatic Thyroid Cancer Therapy Optimization With 124I PET Dosimetry (131THEROPT124)

Failure of conventional radioiodine therapy of metastatic differentiated thyroid cancer could be explained by: a suboptimal therapeutic approach, based on the administration of empirically fixed amount of radioactivity the presence of lesions with impaired iodine uptake, due to the expression of specific mutations The study aims to: optimize therapy with …

  • 0 views
  • 25 Apr, 2022
  • 2 locations
Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism (MVTEP2/SOME2)

occult cancer especially based on FDG PET/CT, and suggests that the best target population for cancer screening would be patients with unprovoked VTE older than 50 years of age (6.7% in patients aged 50

cancer
  • 26 views
  • 22 Mar, 2022
  • 15 locations
Screening for Cancer in Patients With Unprovoked VTE

estimate the impact of an active cancer search strategy using 18-fluordesoxiglucose (FDG) PET-CT in unprovoked VTE with high-risk to develop cancer. Specific Objectives: 1) Number of neoplasms

venous thromboembolic disease
clot
deep vein thrombosis
embolism
thrombosis
  • 0 views
  • 18 Dec, 2021
  • 9 locations
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma the EQUATE Trial

This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, …

plasmacytosis
lenalidomide
electrophoresis
revlimid
daratumumab
  • 21 views
  • 09 Dec, 2021
  • 378 locations
Optimizing Prolonged Treatment in Myeloma Using MRD Assessment (OPTIMUM)

This phase III trial studies how well lenalidomide in combination with ixazomib works compared to lenalidomide alone in treating patients with evidence of residual multiple myeloma after stem cell transplantation. Lenalidomide may help shrink or slow the growth of multiple myeloma. Ixazomib may stop the growth of cancer cells by …

lenalidomide
progressive disease
bone marrow procedure
neutrophil count
platelet count
  • 0 views
  • 22 Oct, 2022
  • 77 locations
A Phase III Randomized Study of Maintenance Nivolumab Versus Observation in Patients With Locally Advanced, Intermediate Risk HPV Positive OPSCC

This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

  • 437 views
  • 23 Oct, 2022
  • 461 locations
Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy (VALOR)

Patients with stage I non-small cell lung cancer have been historically treated with surgery whenever they are fit for an operation. However, an alternative treatment known as stereotactic radiotherapy now appears to offer an equally effective alternative. Doctors believe both are good treatments and are therefore conducting this study to …

metastasis
surgery for lung cancer
lung carcinoma
lung cancer
stage i non-small cell lung cancer
  • 23 views
  • 07 Oct, 2022
  • 16 locations
ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

The primary objective of the the trial is to establish one of three study arms, as future standard based on the comparison of the investigator-assessed failure-free survival.

filgrastim
ara-c
total body irradiation
cyclophosphamide
chop regimen
  • 120 views
  • 23 Feb, 2022
  • 52 locations
Routine Cardiac Screening in Sarcoidosis Patients (PAPLAND)

This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient's history of symptoms and under go an ECG. If a patient has an abnormal …

cardiac sarcoidosis
  • 210 views
  • 15 Feb, 2022
  • 5 locations
COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation

The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable colorectal liver metastases (3cm) and no extrahepatic disease.

metastasis
liver metastasis
  • 33 views
  • 23 Jan, 2021
  • 2 locations