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Found 282 clinical trials
A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH)

The purpose of this study is to see if the study drug, tirzepatide administered once weekly, is safe and effective as a treatment for Nonalcoholic Steatohepatitis (NASH).

  • 212 views
  • 12 May, 2021
  • 166 locations
Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4)

A multi-center evaluation of aldafermin in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis.

fibrosis
mri-pdff
cirrhosis
  • 104 views
  • 08 Apr, 2021
  • 65 locations
A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)

This study will evaluate the effect of each dose of MK-3655 versus placebo on the percentage of individuals with NASH resolution without worsening of fibrosis after 52 weeks. The primary hypothesis of the study is that at least 1 dose of MK-3655 is superior to placebo with respect to the …

  • 0 views
  • 12 May, 2021
  • 72 locations
A Clinical Study to Evaluate the Efficacy and Safety of Aramchol in Subjects With NASH (ARMOR)

An Open-Label Part is added: This part will enroll in selected sites which are less affected by the COVID-19 pandemic. 150 subjects with NASH and fibrosis confirmed by liver histology (F1-F3) will be randomized into 3 groups according to the post-baseline biopsy. The objective of the Open-Label Part is: To …

type 2 diabetes mellitus
body mass index
liver disease
diabetes
fibrosis
  • 65 views
  • 25 Feb, 2021
  • 2 locations
The Danish Childhood Obesity Biobank

The Danish Childhood Obesity Biobank aims to produce a scientific platform for research in obesity: Bio-clinical data are collected from two cohorts - an obesity clinic cohort and a population-based cohort. The biobank thus facilitates translation between research and clinical practice of obesity treatment and related complications.

childhood obesity
obesity treatment
  • 35 views
  • 26 Jan, 2021
  • 2 locations
Habitual Diet and Avocado Trial

The Habitual Diet and Avocado Trial will evaluate the effects of providing one avocado per day for recommended consumption over a 6 month period in a cohort of approximately 1000 free-living participants with increased waist circumference in comparison with a control group that will maintain their habitual diets. Participants will …

  • 843 views
  • 08 Feb, 2021
  • 5 locations
Surveys Blood Testing and Fibroscan in Screening for Liver Fibrosis and Liver Cirrhosis

This clinical trial studies the use of surveys, blood testing, and fibroscan in screening for liver fibrosis and liver cirrhosis in new or existing patients of the HOPE clinic seeking usual clinical care. Fibroscan is an imaging procedure of the liver which uses a probe like an ultrasound. Information gathered …

  • 0 views
  • 15 Mar, 2021
  • 1 location
Outpatient Treatment of COVID-19 With Metformin

The purpose of this trial is to conduct a Stage 1 Substudy powered to detect a difference in continuous laboratory outcomes: Test if metformin treatment in non-hospitalized adults with SARS-CoV-2 infection can prevent hypoxia and emergency department utilization for Covid-19. Test if metformin treatment in non-hospitalized adults with SARS-CoV-2 disease …

  • 0 views
  • 12 May, 2021
  • 1 location
Quantitative US for Evaluation of Hepatic Steatosis in NAFLD

The purpose of this study is to evaluate diagnostic performance of quantitative ultrasonographic parameters for the assessment of hepatic steatosis with find optimal cut-off values in patients

liver disease
fatty liver
magnetic resonance spectroscopy
mri-pdff
alcoholic fatty liver
  • 0 views
  • 26 Mar, 2021
Cold-induced Brown Fat Activation and Hepatic Steatosis

improvements in body fat mass as well as insulin sensitivity. Non-alcoholic fatty liver disease (NAFLD) is estimated to advance to the primary cause of liver cirrhosis and hepatocellular carcinoma in the

fatty liver
body mass index
liver disease
metabolic syndrome
hepatocellular carcinoma
  • 1 views
  • 06 Mar, 2021
  • 1 location