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Found 221 clinical trials
A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)

The purpose of this study is to evaluate the safety and tolerability of single ascending doses of ALN-HSD in healthy participants (Part A) and multiple doses of ALN-HSD in patients with NASH (Parts B and C).

Accepts healthy volunteers
  • 29 Aug, 2023
  • 4 locations
Clinical Outcomes From Enhanced SCREENing Strategies for Advanced NASH in Type 2 Diabetes (SCREEN NASH T2D)

The study is stratified cluster randomized trial (Phase 1) and prospective cohort study and NASH registry (Phase 2). The study population will include adults with T2D and presumed advanced NASH.

  • 08 Sep, 2021
  • 1 location
The Danish Childhood Obesity Biobank

The Danish Childhood Obesity Biobank aims to produce a scientific platform for research in obesity: Bio-clinical data are collected from two cohorts - an obesity clinic cohort and a population-based cohort. The biobank thus facilitates translation between research and clinical practice of obesity treatment and related complications.

obesity treatment
childhood obesity
  • 24 Jan, 2022
  • 1 location
A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD) (LEAP)

set of Cohorts A plus B: To evaluate the effect of REGN4461 on liver fat in patients with hepatic steatosis To evaluate the effect of REGN4461 on hunger To evaluate

  • 05 Sep, 2023
  • 6 locations
Patient-Centered Liver Cancer Prevention in the Houston Community Screening for Predictors of Fibrosis and Cirrhosis

This clinical trial studies the use of surveys, blood testing, and fibroscan in screening for liver fibrosis and liver cirrhosis in new or existing patients of the HOPE clinic seeking usual clinical care. Fibroscan is an imaging procedure of the liver which uses a probe like an ultrasound. Information gathered …

  • 15 Oct, 2022
  • 1 location
Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) Study

Several diets have been proposed to reduce liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD), and various effects on liver steatosis have been observed. The objective of

  • 18 Apr, 2022
Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease

A 2 x 2 cross-over dietary intervention trial designed to investigate the effects of low glycemic index (LGI) versus high glycemic index (HGI) diet on hepatic fat accumulation and gut microbiota composition in participants with NAFLD. Participants will be allocated randomly to a 2-week either high GI (HGI) or low …

  • 09 Oct, 2021
  • 1 location
Lifestyle Modification Programme for HIV-infected Individuals With Fatty Liver

Non-alcoholic fatty liver disease (NAFLD) is rising in prevalence, and will likely become the predominant cause of chronic liver disease in HIV-infected individuals. Metabolic factors and

magnetic resonance spectroscopy
hiv viral load
hiv therapy
liver disease
hiv antibody
  • 01 Sep, 2023
  • 1 location
A Digital Solution for Individuals With Non Alcoholic Fatty Liver Disease

Sidekick Health has developed a digital behavioral change program (SK-241) specifically designed for people with metabolic derangements and non-alcoholic fatty liver disease (NAFLD). The SK-241

  • 15 Jul, 2022
  • 2 locations
Web-based Interventions on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Children

The web-based continuity of care intervention model to provide comprehensive nursing interventions for obese children with NAFLD, always tracking their performance status, enabling them to grasp the knowledge of healthy weight loss, develop good lifestyle habits, and reduce their weight, thus reducing the incidence of NAFLD in children.

Accepts healthy volunteers
  • 07 Oct, 2022
  • 1 location