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Found 626 clinical trials
CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia and currently has no disease modifying treatments or simple accurate diagnostic tests. The goal of this project is to study how tau (a protein thought to cause AD) is made, transported and cleared in the human body. Better understanding of …

alzheimer's disease
neurological disorder
Accepts healthy volunteers
  • 03 May, 2022
  • 1 location
Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound (PRELAPSE)

Rationale Ulcerative colitis (UC) is remitting disease with a variable course. Predicting disease relapse after remission is important for the adjustment of medical treatment. Ileocolonoscopy is the best tool for doing this, but due to its invasiveness should be replaced by a method better accepted by the patient. Gastrointestinal ultrasound …

  • 03 Mar, 2022
  • 2 locations
Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer

Breast cancer is the most common cancer type in European women. Patients treated for early non-metastatic breast cancer comprise a growing group of survivors due to early diagnosis and improved treatment. Many of these survivors experience adverse effects such as decreased bone mineral density, derangement of metabolic markers (fat, glucose, …

type 2 diabetes mellitus
breast cancer
  • 27 Feb, 2022
  • 1 location
Comorbidities and Coinfections in Latent TB (COMBINE-TB)

Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI). The control of TB requires clearly delineated helper T cell (Th) 1 responses and, to a lesser extent, Th17 responses, which both play important roles in the induction and maintenance of …

hemoglobin a1c
  • 04 Oct, 2022
  • 1 location
Prognostic Imaging Biomarkers for Diabetic Kidney Disease (iBEAt)

Diabetic kidney disease (DKD) is a common complication of diabetes, and is now the most common form of chronic kidney disease. DKD is the leading cause of kidney disease requiring dialysis or kidney transplantation, and its global incidence and prevalence have reached epidemic levels. While the risk of developing DKD …

kidney biopsy
diabetic nephropathy
kidney transplant
  • 15 Feb, 2022
  • 2 locations
Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation

Brief Summary: Current U.S. Veteran demographics reveal an aging population with significant cardiovascular dysfunction. This ultimately manifests as mobility limitation, inactivity, and a subsequent worsening of cardiovascular disease (CVD) that often leads to death. However, despite this clear negative cycle of events, there is not a single clinically accepted, and …

cardiac rehabilitation
cardiovascular disease
endothelial dysfunction
Accepts healthy volunteers
  • 21 Mar, 2022
  • 1 location