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Found 23 clinical trials
Featured trial
Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects

The primary objective of this study is:To evaluate the efficacy of fostamatinib when used in combination with standard of care (SOC) in subjects hospitalized with COVID-19 without respiratory failure and with certain high risk prognostic factors, as measured by the change in clinical status score.

covid-19
  • 2 views
  • 10 Dec, 2021
  • 35 locations
Efficacy of Steroid Pulse Therapy in Acute Exacerbation of Idiopathic Pulmonary Fibrosis (AE-IPF) Admitted in ER

complain of dyspnea symptoms due to causes other than the respiratory system, such as fluid overload, congestive heart failure, pulmonary embolism, etc. Patients whose respiratory symptoms have

  • 2 views
  • 18 Aug, 2021
Innovative Technologies for the Treatment of Pulmonary and Heart Failure

The purpose of the program. Formulation of new treatments for heart and pulmonary failure through using organ-replacing technologies. Formulation of a clinical protocol and implementation of treatment methods into clinical practice heart and pulmonary failure using organ-replacing technologies. New methods were created for rehabilitating the function of affected organs after …

vasoconstrictors
pao2
procalcitonin
cytokines
  • 0 views
  • 31 Oct, 2021
  • 1 location
Study on Optimal Oxygen Concentration During Pulmonary Rehabilitation

The purpose of this study is to compare the exercise capacity between high SpO2 (Minimum SpO2 94-96%) value during pulmonary rehabilitation and low SpO2 (Minimum SpO2 84-86%) value during pulmonary rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.

  • 0 views
  • 10 Apr, 2022
  • 1 location
Preventive Versus Curative Treatment of Fluid Overload

Fluid overload is associated with a poor prognosis in critically ill patients, especially during weaning from mechanical ventilation as it may promote weaning induced pulmonary edema. Previous data suggest that early administration of diuretics ("preventive depletion") could shorten the duration of mechanical ventilation. However, this strategy may expose patients to …

mechanical ventilation
critical illness
intubation
positive end expiratory pressure
assisted ventilation
  • 0 views
  • 28 Jul, 2021
  • 1 location
Postpartum NSAIDS and Maternal Hypertension

Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period. NSAIDs remain part of standard postpartum care in women with hypertensive disease. The objective of this study is to …

  • 0 views
  • 26 Jan, 2021
Fluid unLoading On Weaning (FLOW)

The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning from mechanical ventilation in critically ill patients with fluid overload, when compared to a strategy of …

  • 0 views
  • 12 Sep, 2021
  • 1 location
Spironolactone Therapy in Chronic Stable Right HF Trial (STAR-HF)

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in patients with chronic right heart failure.

spironolactone
diuretics
tapse
right ventricular failure
hypertension
  • 66 views
  • 03 Mar, 2022
  • 1 location
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension (REHAB-PH)

This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension. The study will evaluate the safety and clinical efficacy of a 24-week course of famotidine.

vasodilator
right heart catheterization
pulmonary vasodilators
hypertension
  • 55 views
  • 10 Feb, 2022
  • 1 location
Rivet PVS Therapy in Group 2 PH-HFpEF

This clinical investigation is a prospective, multicenter, non-randomized, open-label, Early Feasibility Study to evaluate the safety, performance, and initial clinical efficacy of the Rivet PVS therapy in patients with symptomatic pulmonary hypertension.

  • 0 views
  • 29 Apr, 2022