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Found 11 clinical trials
Pragmatic Randomized Controlled Study to Assess the Effectiveness of Two Patient Management Strategies in Mild to Moderate Ulcerative Colitis (OPTIMISE)

The purpose of this study is to provide evidence that a therapy of Ulcerative Colitis (UC) disease adjusted on tight monitoring of non-invasive parameters, such as clinical symptoms and faecal

  • 2 views
  • 24 Oct, 2022
  • 43 locations
De-escalation of Anti-TNF Therapy in Inflammatory Bowel Disease (FREE)

whether a faecal calprotectin (FC) guided strategy of anti-TNF dosing interval lengthening is non-inferior in maintaining remission in patients with IBD, compared with an unchanged dosing interval.

crohn's disease
luminal
anti-tnf therapy
faecal calprotectin
ulceration
  • 0 views
  • 28 May, 2022
  • 1 location
Impact of Dietary Assessment and Intervention on Outcomes in Liver Cirrhosis Patients

clinical activity measured using endoscopy, faecal calprotectin or radiological evidence of inflammation, currently measured as part of standard practice. Sub-analysis will investigate potential

hepatitis
cancer
cytokines
shear wave elastography
biopsy of liver
  • 6 views
  • 10 May, 2022
  • 1 location
EFFICACI : EFFicacy of Intravenous Infliximab Versus Vedolizumab After Failure of subCutaneous Anti-TNF in Patients With UlCerative Colitis (EFFICACI)

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that results from immune dysregulation. Arguably, the development of Tumor Necrosis Factor (TNF) antagonists (including infliximab, adalimumab and golimumab) revolutionized the management of immune-mediated chronic diseases in the past two decades. However, about one third of patients will not respond …

cancer
inflammatory bowel disease
tumor necrosis factor
intestinal diseases
vedolizumab
  • 22 views
  • 16 Feb, 2022
  • 15 locations
The Intensive Post Exclusive Enteral Nutrition Study

Crohn's disease (CD) is a chronic inflammatory condition with phases where the disease is active and other, where there are no symptoms. Exclusive enteral nutrition (EEN), a liquid only diet without allowance of any extra food, is the main treatment for children with active CD. However, when children stop the …

crohn's disease
enteral nutrition
  • 0 views
  • 24 Jan, 2021
  • 5 locations
Prevention of Inflammatory Bowel Diseases in Persons at Risk The PIONIR (Preventing IBD Onset in Individuals at Risk) Trial (PIONIR)

The goal of this study is to explore in a cross over randomized controlled trial, the ability of the Tasty&Healthy dietary intervention (NCT04239248) to alter the parameters associated with future risk of developing Chron's disease (CD) using subjects identified in the Genetic Environmental Microbiome (GEM) Study as having a high-risk …

Accepts healthy volunteers
endoscopy
faecal calprotectin
ulceration
enteropathy
  • 0 views
  • 25 Mar, 2022
  • 1 location
Efficacy of Energy Therapy in the Management of Chronic Pain Medical Condition in Children and Adolescents. (ET&CP)

Paediatric and adolescent patients with chronic pain associated with their medical condition will be invited to participate in this study. Most patients for this study will be recruited from gastroenterology and hepatology clinics at KCH. Therefore the rationale for the study is primarily with consideration of each of these medical …

crohn's disease
inflammatory bowel disease
enteropathy
ulceration
ulcerative colitis
  • 0 views
  • 04 Jun, 2022
  • 1 location
Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis

inflammatory markers- faecal calprotectin. Secondary variables: recurrence of acute diverticulitis -the persistence of symptoms - SF 12 and GIQLI questionnaires. STATISTICS: Sample size: alpha error

  • 0 views
  • 24 Jan, 2021
  • 1 location
Real-world Effectiveness of Tofacitinib on Ulcerative Colitis Associated Spondyloarthropathy (RETUCAS)

Tofacitinib (TOFA) is a JAK inhibitor already used in rheumatology for the treatment of moderate-to-severe active rheumatoid arthritis and psoriatic arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease- modifying antirheumatic drugs. Furthermore, TOFA has been recently approved for the treatment …

  • 0 views
  • 09 Jul, 2022
  • 1 location
Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound (PRELAPSE)

Rationale Ulcerative colitis (UC) is remitting disease with a variable course. Predicting disease relapse after remission is important for the adjustment of medical treatment. Ileocolonoscopy is the best tool for doing this, but due to its invasiveness should be replaced by a method better accepted by the patient. Gastrointestinal ultrasound …

  • 18 views
  • 03 Mar, 2022
  • 2 locations