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Found 10 clinical trials
A Randomized Clinical Trial of Andexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor Xa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet alfa versus usual care in patients with intracranial hemorrhage anticoagulated with a direct oral or indirect subcutaneous/intravenous anticoagulant

  • 34 views
  • 19 Sep, 2022
  • 170 locations
Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement (RENOVATE)

This study evaluates the long-term anticoagulation with oral factor Xa inhibitor versus vitamin K antagonist in patients receiving a mechanical aortic valve replacement.

warfarin
rivaroxaban
factor xa inhibitor
regurgitation
  • 0 views
  • 09 Aug, 2022
  • 1 location
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement (PEPPER)

PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.

warfarin
rivaroxaban
total knee replacement
pulmonary embolism
embolism
  • 340 views
  • 25 Feb, 2022
  • 20 locations
Study of OCTAPLEX in Patients With Acute Major Bleeding on DOAC Therapy With Factor Xa Inhibitor

prothrombin complex concentrate, OCTAPLEX, in patients with acute major bleeding on DOAC therapy with factor Xa inhibitor. Patients will be randomised 1:1 to either of two study groups: low-dose vs. high-dose

  • 0 views
  • 07 Jun, 2022
  • 4 locations
A Phase 3, Prospective, Randomized, Open-label, Adaptive Group Sequential, Multicenter Trial With Blinded Endpoint Assessment to Evaluate the Efficacy and Safety of PROTHROMPLEX TOTAL for the Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation in Patients Requiring Urgent Surgery/Invasive Procedure

The aim of this study is to examine the potential of PROTHROMPLEX TOTAL compared to investigator-assigned four-factor prothrombin complex concentrate (4F-PCC) as a part of SOC for the reversal of anticoagulation in participants treated with Factor Xa inhibitors who require urgent surgery/invasive procedure. The participant will be randomized to PROTHROMPLEX …

  • 0 views
  • 18 Sep, 2022
Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD)

The Study is an open-labeled, randomized controlled trial, phase IIIb. Its objective is to assess the safety of the factor Xa inhibitor apixaban versus the vitamin-K antagonist (VKA

chronic haemodialysis
stroke
holter monitor
apixaban
embolism
  • 14 views
  • 06 May, 2021
  • 3 locations
Effects of Edoxaban on Platelet Aggregation

, inflammatory markers will be, at same way, assessed at baseline and after intervention each phase: ultrasensitive C-reactive protein (us-PCR). Keywords: edoxaban, direct factor Xa inhibitor, stable

stroke
coronary artery bypass graft
angiography
antiplatelet agents
coronary angioplasty
  • 0 views
  • 22 Nov, 2021
  • 1 location
Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis

The goal of this study is to determine the safety and tolerability or efficacy of adjunctive treatments (including rosuvastatin 20 mg daily) in combination with standard anticoagulation therapy (Factor Xa inhibitors) in patients with lower extremity deep vein thrombosis (DVT). The efficacy of adjunctive treatments to prevent the development of …

  • 0 views
  • 22 Oct, 2021
  • 1 location
Residual Anti-Xa Activity After Last Treatment Dose of Enoxaparin

The main objective of this study is to determine the time interval following the last treatment dose of enoxaparin at which the amount of anti-Xa level activity is reliably less than 0.2IU/mL in patients presenting for elective surgery.

enoxaparin
elective surgery
  • 6 views
  • 24 Dec, 2021
  • 1 location
Ondexxya for Intravenous Injection 200mg Drug Use Result Investigation (All Case Investigation)

This survey will be conducted to investigate the status of occurrence of the safety specifications set for "Safety specification" in patients who received Ondexxya Intravenous Injection 200 mg. In addition, this survey will be implemented to understand the followings by collecting safety and effectiveness information under actual use conditions.

  • 0 views
  • 18 Sep, 2022
  • 4 locations