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Found 63 clinical trials
A Phase II/III, Multicentre, 8-week run-in Phase Followed by a 12-week, Prospective, Parallel-group, Double-blind, Randomized Withdrawal, Placebo-controlled Study, With a 52 Week Open Label Extension, to Evaluate the Efficacy and Safety of Daily 1.5 to 3.5 mg Basimglurant in Patients With Pain Associated With Trigeminal Neuralgia With Suboptimal Response to Their Current Anti-pain Therapy.

Trigeminal neuralgia (TN), also called "tic douloureux", is the most common form of craniofacial neuropathic pain and is considered the cause of one of the most painful afflictions known in medical practice. This study is designed to evaluate the efficacy and safety of 1.5mg - 3.5mg basimglurant in adults with …

ache
  • 194 views
  • 14 Oct, 2022
  • 14 locations
Investigate the Change in Facial Pain Threshold During Auricular Acupuncture in Healthy Volunteers

Pharmacy, Ho Chi Minh City and clinical studies to be effective in reducing facial pain. This study aims to examine: (1) the change in facial pain threshold when performing auricular acupuncture in

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Dissecting the Heterogeneity of Oral Cancer Pain

Oral squamous cell carcinoma (SCC) produces a higher prevalence and more severe pain than all other cancers. Orofacial pain is one of the most common initial symptoms of oral cancer and often

Accepts healthy volunteers
  • 0 views
  • 17 Oct, 2022
  • 1 location
Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis

to. The surgeon will know the group. The same pain and nausea medications will be ordered for all participants after the surgery. Pain scores will be measured using the Faces Pain Scale

  • 0 views
  • 04 Oct, 2022
  • 1 location
Erenumab-aooe for the Management of Trigeminal Neuropathic Pain.

This study is a single center, placebo-controlled, double blind, randomized, phase II pilot to evaluate the efficacy of erenumab-aooe in the management of trigeminal neuropathic pain comparing erenumab-aooe vs Placebo. A total of 40 patients (20 each arm) aged 18-65 years old of either sex, and any race or ethnicity, …

  • 0 views
  • 15 May, 2022
  • 1 location
Use of Passive Myofunctional Appliances for Snoring and Mild Obstructive Sleep Apnea

It is unknown whether passive myofunctional appliances can be used for the treatment of obstructive sleep apnea and snoring, nor how to select the appropriate size per individual patient. Exploring the possibility of using passive myofunctional appliances as a treatment option for patients with mild obstructive sleep apnea and/or snoring …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Dupilumab for Prevention of Recurrence of CRSwNP After ESS

The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus environment and will allow for better coordinated and more effective mucosal healing. Specifically, the investigators believe that endoscopic signs …

  • 1 views
  • 13 Jun, 2021
  • 1 location
Multi-center Randomized Pilot Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies (TRICS-9)

Phase II, prospective, randomized, multicenter, open-label, pilot clinical trial comparing remote ischemic conditioning (RIC) plus standard medical therapy to standard medical therapy alone, in patients with acute ischemic stroke within 9 hours of stroke onset that are not eligible to recanalization therapies.

  • 10 views
  • 19 Oct, 2022
  • 3 locations
Erenumab for Idiosyncratic Facial Pain

This is a phase IV randomized, double-blinded, placebo-controlled study to evaluate the efficacy of Erenumab in subjects with midfacial pain or pressure, without clinical or radiographic evidence of sinusitis.

edema
  • 0 views
  • 10 Jul, 2022
  • 1 location
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management

The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a placebo. The hypothesis is that combined ibuprofen and acetaminophen therapy will effectively provide better pain …

pain relieving
analgesics
analgesia
Accepts healthy volunteers
  • 3 views
  • 23 May, 2022
  • 1 location