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Found 980 clinical trials
Featured trial
A Trial Evaluating Different Dosing Durations of TEPEZZA® Treatment in Patients with Thyroid Eye Disease (TED)

The overall objective is to investigate the safety, tolerability and need for re-treatment of 3 different TEPEZZA® treatment durations (4, 8, or 16 infusions) in patients with TED.

  • 0 views
  • 20 May, 2022
  • 2 locations
Featured trial
Study to evaluate TEPEZZA® in patients with Chronic (Inactive) Thyroid Eye Disease (TED)

The goal is to determine the efficacy, safety and tolerability of TEPEZZA® for treating chronic (inactive) TED. About 57 participants will start with a 24-week treatment period. Patients that do not meet the desired response after the 24-week treatment period may receive up to 8 additional infusions of TEPEZZA®.  After …

  • 0 views
  • 20 May, 2022
  • 9 locations
Featured trial
Featured trial
A Phase 2, Multicenter, Randomized, Controlled, Double-Masked, Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray in Subjects With Neurotrophic Keratopathy (the Olympia Study)

The objective of this study is to evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray as compared to placebo nasal spray for mean change from baseline in corneal fluorescein staining in subjects with Stage 1 (corneal epithelial hyperplasia/punctate keratopathy) neurotrophic keratopathy (NK) in one or both eyes.

  • 0 views
  • 10 Mar, 2022
  • 1 location
3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)

complications in Dry Eye Disease (DED) patients with severe keratitis receiving Ikervis (1mg/mL ciclosporin) eye drops administered once daily

  • 210 views
  • 16 Feb, 2022
  • 13 locations
Village Integrated Eye Workers Trial

VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained to diagnose and treat corneal abrasions and villages which receive no intervention.

  • 241 views
  • 10 Oct, 2021
  • 1 location
Alpha MSH in Ocular Disease

The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease. Alpha MSH has been shown to have an important role in the regulation of ocular immunity in animal models of inflammatory retinal …

Accepts healthy volunteers
  • 38 views
  • 27 Feb, 2022
  • 1 location
Anti-VEGF Therapy for Acute Thyroid Eye Disease (AcTED)

The primary objective is to assess the safety and tolerability of sub-tenon aflibercept in combination with either saline or hyaluronidase (HA) in patients with acute Thyroid Eye Disease (TED

  • 0 views
  • 15 Mar, 2022
  • 1 location
Bimatoprost as a Treatment for Graves' Orbitopathy

Testing whether Bimatoprost, a topical eye drop used for glaucoma, can be used to induce periorbital fat atrophy in patients with Graves' disease

glaucoma
graves' disease
exophthalmos
eye disease
  • 88 views
  • 10 Apr, 2022
  • 1 location
A Study to Evaluate the Efficacy and Safety of HBM9161 on Moderate to Severe Thyroid Eye Disease

Primary Objective: To preliminarily evaluate the efficacy of the treatment regimen of HBM9161 680 mg administered subcutaneously weekly and sequentially every other week for 12 weeks in Chinese patients with active moderate to severe TED.

  • 0 views
  • 17 Mar, 2022
  • 1 location