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Found 15 clinical trials
Phase II Study of Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

Background Bile duct cancer is cancer of the slender tubes of the biliary tract. These tubes carry bile through the liver. Such cancer tumors often have an abnormal or mutated gene. Researchers think a mix of drugs can slow the progression of gene-mutated cancers of the biliary tract. Objective To …

hydroxychloroquine
cancer
EGFR
KRAS
measurable disease
  • 0 views
  • 19 Sep, 2022
  • 1 location
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers (FBI-TRAC)

This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess progression free survival and overall survival of FOLFIRINOX in first line treatment of advanced biliary tract cancers

oxaliplatin
Accepts healthy volunteers
irinotecan
leucovorin
measurable disease
  • 5 views
  • 25 Feb, 2022
  • 1 location
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors (PORTAL)

This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.

ct scan
cancer
premalignant
pancreaticoduodenectomy
mri liver
  • 0 views
  • 13 May, 2022
  • 1 location
Biomarker Discovery in Patients With Advanced Biliary Tract Cancer

Biliary tract cancer is a rare gastrointestinal malignant neoplasm and includes intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gall bladder cancer. Curative surgical

paclitaxel
cancer
gemcitabine
  • 0 views
  • 13 Aug, 2021
  • 1 location
Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer

This study is going to test the ability to successfully obtain results from certain personalized tests for patients with biliary tract cancers that are able to be surgically removed. Through surveys, this study will also evaluate the usefulness of these tests to medical oncologists as they make decisions on what …

neutrophil count
renal function
cancer
anesthesia
  • 0 views
  • 22 Jul, 2022
  • 1 location