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Found 49 clinical trials
Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cáncer

Open, multicentre, phase II trial of atezolizumab with concurrent normofractionated radiotherapy in patients with localized muscle-invasive bladder cancer treated with a selective multimodality bladder conservative approach.

bladder cancer
invasive bladder cancer
radical cystectomy
neutrophil count
  • 20 Feb, 2022
  • 10 locations
High Five (HiFi) Accelerated Partial Breast Irradiation Study

To establish the role of adjuvant multicatheter interstitial high-dose-rate brachytherapy in doubly accelerated and radiobiologically equivalent irradiation scheme of 5 x 5,4 Gy in 3 days of treatment (High Five, HiFi-APBI) compared to the adopted long-term standard of APBI realized in 4-5 days (7-8 x 4-4,3 Gy) in selected women …

her2/neu-positive breast cancer
breast-conserving surgery
invasive carcinoma
  • 10 Dec, 2021
  • 1 location
Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

This phase I trial is to find out the possible side effects of pembrolizumab and radiation therapy before and during surgery in treating patients with head and neck squamous cell cancer that remains despite treatment (persistent) or has come back (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help …

  • 10 Mar, 2022
  • 1 location
Optimizing Prostate Cancer Treatment in Men With Advanced Local Disease (OPTiMAL)

Multi-modality therapy that includes a brachytherapy implant improves outcomes in locally advanced prostate cancer when compared to other radiation-based treatments, but is also associated with more adverse side effects. The goal of the OPTiMAL trial is to reduce these side effects by using advanced imaging and biopsy techniques to locate …

ct scan
external beam radiation therapy
androgen suppression
transrectal ultrasound
  • 12 Feb, 2022
  • 1 location
A First Step Towards Ultra-hypofractionation for Unfavourable Intermediate and High-risk Prostate Cancer (UPRATE)

This study aims to make a first step towards ultra-hypofractionation for high-risk prostate cancer by proving the technical feasibility of margin reduction of the seminal vesicles by combining the intra-fraction fiducial tracking with an online re-planning workflow for each fraction to account for the inter-fraction seminal vesicle motion.

  • 04 Oct, 2022
  • 1 location
Proton Therapy Medical Registry

Clínica Universidad de Navarra Proton Therapy Unit is establishing a registry to capture the full radiation dosimetry delivered to the patient, baseline clinical data, and disease, toxicity and quality of life outcomes. The objectives are parameters prescribed and to have all patients treated at the proton therapy unit to be …

  • 15 Dec, 2021
  • 2 locations
Early Activation of Artificial Urinary Sphincter (WV_AUS)

reason for urinary incontinence in men is related to treatment for prostate cancer. These treatment options can range from surgical removal of the prostate, external beam radiation therapy, and/or

Accepts healthy volunteers
  • 14 Feb, 2022
  • 1 location
Multi-Atlas and Whole Body Radiomics Approaches for Image-Guided Treatment of Gynecologic Cancers

To compare acute toxicity and chemotherapy delivery for atlas-based IG-IMRT vs. PET/CT-based IG-IMRT vs. conventional RT, and assess the impact of treatment on changes in hematopoietic compensatory response. To develop and validate machine learning and radiomics techniques for dose accumulation, automated treatment planning, and prediction of treatment response.

  • 15 May, 2022
  • 1 location
Prospective Evaluation of Interventional Studies on Bone Metastases - the PRESENT Cohort

Bone metastases are frequent distant manifestations of cancer, with pain as a common and devastating consequence. The primary treatment for painful bone metastases, external beam radiation

  • 23 Jan, 2021
  • 1 location