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Found 68 clinical trials
A Study of MTL-CEBPA in Combination With a PD-1 Inhibitor in Patients With Advanced Solid Tumours (TIMEPOINT)

This is an open label Phase 1a/1b study in patients who have advanced solid cancer tumours. Patients will receive MTL-CEBPA (an experimental drug) in combination with pembrolizumab (a drug which

hysterectomy
pembrolizumab
pd-l1
cancer
solid tumour
  • 0 views
  • 30 Jan, 2021
  • 3 locations
Itacitinib for Low Risk GVHD

treated with itacitinib instead of steroids. Itacitinib is an experimental drug with an excellent safety record and appears to have activity as a GVHD treatment.

transplant conditioning
platelet count
systemic steroids
neutrophil count
experimental drug
  • 1 views
  • 27 Jan, 2021
  • 13 locations
INCMGA00012 (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

treatment for your disease. Gemcitabine and docetaxel are chemotherapy drugs that are commonly used to treat soft tissue sarcoma. INCMGA00012 is an experimental drug that boosts the immune system's ability

neutrophil count
gemcitabine
measurable disease
systemic therapy
cancer chemotherapy
  • 0 views
  • 30 Apr, 2021
  • 1 location
Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

that uses a laser to heat brain tumors. Pembrolizumab is an investigational (experimental) drug that works by helping participants' immune system work correctly to detect and fight cancer cells

  • 15 views
  • 12 May, 2021
  • 2 locations
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

treatment for brain cancer, temozolomide and radiation. Ruxolitinib is an experimental drug that works by targeting proteins in cells and stops them from growing. Ruxolitinib is experimental because

MRI
anaplastic oligodendroglioma
karnofsky performance status
astrocytoma, anaplastic
malignant brain tumor
  • 31 views
  • 09 Apr, 2021
  • 1 location
A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer

This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used

metastatic cancer
platinum-based chemotherapy
enfortumab vedotin
experimental drug
pembrolizumab
  • 284 views
  • 29 Apr, 2021
  • 82 locations
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective

stem cell transplantation
experimental drug
isof
antineoplastic
chemotherapeutic agents
  • 3 views
  • 24 Jan, 2021
  • 1 location
Safety and Efficacy of OT-82 in Participants With Relapsed or Refractory Lymphoma

This research study will test OT-82, which is an investigational ("research" or "experimental" ) drug. The study has two stages (Stage 1 and Stage 2). The purpose of Stage 1 is to determine the

hysterectomy
chronic lymphocytic leukemia
stem cell transplantation
refractory lymphoma
hodgkin's disease
  • 3 views
  • 26 Jan, 2021
  • 8 locations
Dose Escalation Safety Study of TMB-365 in HIV-1 Infected Participants

This study will evaluate the safety and behavior in the body of the experimental drug TMB-365 in people with HIV-1 infection. This will be the first test of TMB-365 in humans. One dose of the

  • 4 views
  • 05 Apr, 2021
  • 7 locations
DS-3201b in Participants With Lymphomas

DS-3201b is an experimental drug. It is not approved for regular use. It can only be used in clinical research. Adults with non-Hodgkin lymphoma (NHL) might be able to join this study if

hodgkin's disease
remission
cancer
experimental drug
  • 0 views
  • 01 May, 2021
  • 2 locations